The role of regulatory T cells in the biology of graft versus host disease.
The role of regulatory T cells in the biology of graft versus host disease.
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DOI：
10.3389/fimmu.2013.00163
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发表时间：
2013
影响因子：
7.3
通讯作者：
Drobyski WR
中科院分区：
文献类型：
--
作者：
Beres AJ;Drobyski WR
移植物抗宿主病（GVHD）是异基因造血干细胞移植的主要并发症。GVHD的特征在于免疫系统的效应臂和调节臂之间的不平衡，这导致炎性细胞因子的过度产生。此外，调节性T（Treg）细胞的数量持续减少，这限制了免疫系统重新校准这种促炎环境的能力。Treg细胞由天然和诱导群体组成，其具有独特的本体和发育特征，这些特征影响它们在免疫调节背景下如何发挥功能。在这篇综述中，我们总结了来自实验小鼠模型的临床前数据，研究了天然和诱导Treg细胞在GVHD生物学中的作用。我们还回顾了临床研究，已经开始采用Treg细胞作为一种形式的过继细胞治疗，用于预防移植受者的GVHD。
Graft versus host disease (GVHD) is the major complication of allogeneic hematopoietic stem cell transplantation. GVHD is characterized by an imbalance between the effector and regulatory arms of the immune system which results in the over production of inflammatory cytokines. Moreover, there is a persistent reduction in the number of regulatory T (Treg) cells which limits the ability of the immune system to re-calibrate this proinflammatory environment. Treg cells are comprised of both natural and induced populations which have unique ontological and developmental characteristics that impact how they function within the context of immune regulation. In this review, we summarize pre-clinical data derived from experimental murine models that have examined the role of both natural and induced Treg cells in the biology of GVHD. We also review the clinical studies which have begun to employ Treg cells as a form of adoptive cellular therapy for the prevention of GVHD in human transplant recipients.
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影响因子：
32.4
作者：
Fontenot, JD;Rasmussen, JP;Rudensky, AY
通讯作者：
Rudensky, AY
影响因子：
2.2
作者：
Bremm, Melanie;Huenecke, Sabine;Koehl, Ulrike
通讯作者：
Koehl, Ulrike
DOI：
10.4049/jimmunol.1200886
发表时间：
2012-07-01
期刊：
Journal of immunology (Baltimore, Md. : 1950)
影响因子：
--
作者：
Beres AJ;Haribhai D;Chadwick AC;Gonyo PJ;Williams CB;Drobyski WR
通讯作者：
Drobyski WR
DOI：
10.1016/j.bbmt.2011.07.001
发表时间：
2011-12
期刊：
Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation
影响因子：
--
作者：
Drobyski WR;Pasquini M;Kovatovic K;Palmer J;Douglas Rizzo J;Saad A;Saber W;Hari P
通讯作者：
Hari P
影响因子：
5.4
作者：
Albert, MH;Liu, Y;Yu, XZ
通讯作者：
Yu, XZ