Strategies for potentiation of ethionamide and folate antagonists against Mycobacterium tuberculosis.
Strategies for potentiation of ethionamide and folate antagonists against Mycobacterium tuberculosis.
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DOI：
10.1586/eri.12.87
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发表时间：
2012-09
影响因子：
5.7
通讯作者：
Nguyen L
中科院分区：
文献类型：
--
作者：
Wolff KA;Nguyen L
抗叶酸剂抑制叶酸从头生物合成，而乙硫异烟胺靶向结核分枝杆菌中的分枝菌酸合成途径。这些抗生素对M.结核病，但它们的使用受到对毒性和低治疗指数的担忧的阻碍。随着耐药形式的日益蔓延，人们重新对使用旧药物治疗结核病产生了兴趣。针对耐药机制的特异性抑制剂可使M.结核病，这些可用的，临床批准的药物。本文综述了最近开发的策略，以提高乙硫异烟胺和抗叶酸剂的抗结核活性。这些方法可能有助于拓宽目前有限的耐药结核病和药敏结核病的化疗选择，结核病仍然是发展中国家最常见的传染病之一。
Antifolates inhibit de novo folate biosynthesis, whereas ethionamide targets the mycolate synthetic pathway in Mycobacterium tuberculosis. These antibiotics are effective against M. tuberculosis but their use has been hampered by concerns over toxicity and low therapeutic indexes. With the increasing spread of drug-resistant forms, interest in using old drugs for tuberculosis treatment has been renewed. Specific inhibitors targeting resistance mechanisms could sensitize M. tuberculosis to these available, clinically approved drugs. This review discusses recently developed strategies to boost the antituberculous activity of ethionamide and antifolates. These approaches might help broaden the currently limited chemotherapeutic options of not only drug-resistant but also drug-susceptible tuberculosis, which still remains one of the most common infectious diseases in the developing world.
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影响因子：
5.6
作者：
Baca, AM;Sirawaraporn, R;Hol, WGJ
通讯作者：
Hol, WGJ
影响因子：
2.9
作者：
Argyrou, Argyrides;Jin, Lianji;Blanchard, John S.
通讯作者：
Blanchard, John S.
DOI：
10.1093/jhmas/jrq068
发表时间：
2011-10-01
影响因子：
0.5
作者：
Barr, Justin
通讯作者：
Barr, Justin
DOI：
10.1099/mic.0.053983-0
发表时间：
2012-02
期刊：
Microbiology (Reading, England)
影响因子：
--
作者：
Fivian-Hughes AS;Houghton J;Davis EO
通讯作者：
Davis EO
影响因子：
56.3
作者：
Caminero, Jose A.;Sotgiu, Giovanni;Migliori, Giovanni Battista
通讯作者：
Migliori, Giovanni Battista