Collagen and Hydroxyapatite Composite Membranes as Drug-Carrying Support for Biomedical Applications
Collagen and Hydroxyapatite Composite Membranes as Drug-Carrying Support for Biomedical Applications
复制标题
胶原和羟基磷灰石复合膜作为生物医学应用的载药支持
DOI：
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发表时间：
2017
期刊：
影响因子：
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通讯作者：
T. Ikoma
中科院分区：
文献类型：
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作者：
Daichi Kajiwara;T. Ikoma
由设备和药物组成的医疗产品一直被称为组合产品。将重组人骨形态发生蛋白植入可生物降解的胶原海绵中，可促进骨形成。通过多种生长因子和人工骨材料的结合，有望获得进一步的特征。这些因子与胶原和羟基磷灰石(HAP)的结合特性尚未阐明以实现控释。在这项研究中，我们研究了罗非鱼胶原和羟基磷灰石复合材料制成的人工骨膜样膜作为药物载体。采用γ射线辐照湿法制备了3种不同质量比为2：8、5：5和8：2的Col-HAP复合材料。膜在湿态或干态下的拉伸强度取决于膜的组成，但在湿态下，膜的强度明显弱于干态，最大为90 Mpa。蛋白质，牛血清白蛋白(BSA)和溶菌酶(LSZ)在膜上的吸附能力表现出不同的趋势；HAP质量比较高的膜吸附BSA而不是LSZ。这些结果表明，人工Col-HAP膜作为组合产品有望成为生物医学装置的理想材料。
Medical products comprised of devices and drugs have been known as a combination product. The biodegradable collagen (Col) sponges impregnated with recombinant human bone morphogenetic protein can make bone formation hasten. It is expected further features by a combination of various growth factors and artificial bone materials. The binding properties of such factors to Col and hydroxyapatite (HAp) have not been elucidate to achieve a controlled release. In this study, we investigated artificial periosteum-like membranes made from tilapia fish Col and HAp composites as a drug carrying support. The Col-HAp composites with three different compositions in weight ratio of 2:8, 5:5 and 8:2 were made and crosslinked by irradiation of gamma-ray in wet condition. The tensile strengths of the membranes in wet or dry were depended on the compositions; however the strengths of the membranes in wet were apparently weaker at 1/10 or less than those in dry at a maximum 90 MPa. The adsorption ability of proteins, bovine serum albumin (BSA) or lysozyme (LSZ), on the membranes exhibited different tendency; the membranes including higher weight ratio of HAp adsorbed BSA rather than LSZ. These results indicated that the artificial Col-HAp membranes would be the suitable materials for biomedical device as combination products.
影响因子：
9.7
作者：
Walters, B. D.;Stegemann, J. P.
通讯作者：
Stegemann, J. P.