Irisin reduces inflammatory signaling pathways in inflammation-mediated metabolic syndrome.
Irisin reduces inflammatory signaling pathways in inflammation-mediated metabolic syndrome.
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DOI：
10.1016/j.mce.2022.111676
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发表时间：
2022-07-15
影响因子：
4.1
通讯作者：
Zhao, Ting C.
中科院分区：
文献类型：
--
作者：
Slate-Romano, John J.;Yano, Naohiro;Zhao, Ting C.
鸢尾素是一种运动诱导的肌因子，首次被证明可以诱导白色脂肪组织（WAT）褐变，从而增加能量消耗，提高葡萄糖耐量，降低胰岛素抵抗。鸢尾素参与脂质稳态、成骨细胞增殖和肌肉生长，它还作为全身许多炎症途径的中介。本文旨在描述鸢尾素在炎症过程中的作用，并了解靶向鸢尾素如何改变代谢综合征（MetS）的炎症反应。鸢尾素抗炎作用的机制包括减少促炎细胞因子的产生，同时增加抗炎细胞因子的产生，减少巨噬细胞的增殖，诱导选择性活化（m2型）巨噬细胞极化，抑制血管通透性增加的途径，防止炎症小体的形成。虽然有一些相互矛盾的结果，但大多数研究发现，在MetS和2型糖尿病（T2DM）中，鸢尾素水平降低。鸢尾素治疗暴露于炎症刺激的细胞可改善炎症反应并促进细胞活力。已经研究了许多提高血浆中鸢尾素水平的方法，包括饮食、行为和药物。进一步的研究是必要的，以了解如何鸢尾素可以靶向疾病改造。
Irisin is an exercise induced myokine first shown to induce the browning of white adipose tissue (WAT) which increases energy expenditure, improves glucose tolerance, and reduces insulin resistance. Among irisin’s involvement in lipid homeostasis, osteoblast proliferation, and muscle growth, it also acts as a mediator of many inflammatory pathways throughout the body. This review aims to describe the role of irisin in inflammatory processes and understand how targeting irisin can alter the inflammatory response in metabolic syndrome (MetS). The mechanisms involved in irisin’s anti-inflammatory functions include reducing production of pro-inflammatory cytokines while increasing production of anti-inflammatory cytokines, reducing macrophage proliferation, inducing alternatively activated (M2-type) macrophage polarization, inhibiting pathways of increased vascular permeability, and preventing the formation of inflammasomes. While there are some contradictory results, most studies found reduced levels of irisin in MetS and type II diabetes mellitus (T2DM). Irisin treatment of cells exposed to inflammatory stimuli ameliorates the inflammatory response and promotes cellular viability. Numerous methods have been studied to increase plasma irisin levels including dietary, behavioral, and pharmaceutical. Further investigation is necessary to understand how irisin can be targeted for disease modification.
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