Update on biology and management of mesothelioma.
Update on biology and management of mesothelioma.
复制标题
DOI：
10.1183/16000617.0226-2020
复制
发表时间：
2021-03-31
影响因子：
7.5
通讯作者：
Rahman, Najiib M.
中科院分区：
文献类型：
--
作者：
Asciak, Rachelle;George, Vineeth;Rahman, Najiib M.
恶性胸膜间皮瘤是一种侵略性，无法治愈的癌症，通常是由石棉暴露几十年前出现症状。尽管广泛禁止石棉的生产和供应，但其发生率继续增加。它的表现和行为是异质性的，诊断可能是出了名的困难。鉴定可操作的基因突变已被证明具有挑战性，目前的治疗方案在很大程度上是无效的，中位生存期为10 - 12个月。 然而，在过去的几年里，我们对间皮瘤的生物学和发病机制的认识取得了重大进展。这也揭示了现有诊断算法的局限性，并确定了新的治疗靶点。最近的临床试验重新审视了手术的作用，为相关胸腔积液的管理提供了新的选择，并预示着靶向治疗的增加。间皮瘤管理的日益复杂性，沿着迫切需要进一步的研究，意味着一个多学科的团队框架是必不可少的提供当代间皮瘤护理。这篇综述提供了一个综合的概述，目前的知识和更新的最新研究领域。尽管对恶性胸膜间皮瘤的发病机制有了更好的了解，但缺乏能显著提高生存率的有效治疗。正在进行的研究可能会确定可能从手术治疗中受益的选定患者群体。https://bit.ly/3k16J9O
Malignant pleural mesothelioma is an aggressive, incurable cancer that is usually caused by asbestos exposure several decades before symptoms arise. Despite widespread prohibition of asbestos production and supply, its incidence continues to increase. It is heterogeneous in its presentation and behaviour, and diagnosis can be notoriously difficult. Identification of actionable gene mutations has proven challenging and current treatment options are largely ineffective, with a median survival of 10–12 months. However, the past few years have witnessed major advances in our understanding of the biology and pathogenesis of mesothelioma. This has also revealed the limitations of existing diagnostic algorithms and identified new treatment targets. Recent clinical trials have re-examined the role of surgery, provided new options for the management of associated pleural effusions and heralded the addition of targeted therapies. The increasing complexity of mesothelioma management, along with a desperate need for further research, means that a multidisciplinary team framework is essential for the delivery of contemporary mesothelioma care. This review provides a synthesised overview of the current state of knowledge and an update on the latest research in the field. Despite a better understanding of the pathogenesis of malignant pleural mesothelioma, effective treatment that prolongs survival significantly is lacking. Ongoing research may identify select patient groups that may benefit from surgical treatment. https://bit.ly/3k16J9O
登录
查看更多内容
影响因子：
5.3
作者：
Boshuizen, R. C.;Vander Noort, V.;van den Heuvel, M. M.
通讯作者：
van den Heuvel, M. M.
影响因子：
4.4
作者：
Bhatnagar, Rahul;Maskell, Nick
通讯作者：
Maskell, Nick
DOI：
10.4103/0019-5278.146897
发表时间：
2014-05
影响因子：
0.9
作者：
Bianchi C;Bianchi T
通讯作者：
Bianchi T
DOI：
10.1002/mpo.2950090409
发表时间：
1981-01-01
期刊：
MEDICAL AND PEDIATRIC ONCOLOGY
影响因子：
--
作者：
BRENNER, J;SORDILLO, PP;MAGILL, GB
通讯作者：
MAGILL, GB
影响因子：
10
作者：
BARIS, YI;SAHIN, AA;GOKTEPELI, A
通讯作者：
GOKTEPELI, A