Physiological relevance of post-translational regulation of the spindle assembly checkpoint protein BubR1.
Physiological relevance of post-translational regulation of the spindle assembly checkpoint protein BubR1.
复制标题
纺锤体组装检查点蛋白 BubR1 翻译后调节的生理相关性。
DOI：
10.1186/s13578-021-00589-2
复制
发表时间：
2021-04-23
影响因子：
7.5
通讯作者：
North BJ
中科院分区：
文献类型：
--
作者：
Bloom CR;North BJ
BubR1是有丝分裂过程中纺锤体组装检查点（SAC）的重要组成部分，其功能是防止后期开始，以确保正确的染色体排列和着丝点-微管附着。BubR1的缺失或突变导致非整倍性，而非整倍性先于各种潜在的病理，包括癌症和马赛克杂色非整倍性（MVA）。BubR1也随着年龄的增长而逐渐下调，并已被证明通过抑制细胞衰老直接参与衰老过程。包括但不限于磷酸化、乙酰化和泛素化在内的翻译后修饰在BubR1功能的时空调控中起着关键作用。在这篇综述中，我们讨论了目前已知的对BubR1的翻译后修饰、所涉及的酶、对BubR1功能的生物学影响以及与BubR1相关的疾病的意义。了解促进这些修饰的分子机制及其在调节BubR1中的作用，对于我们目前和未来研究BubR1在维持基因组完整性以及衰老和癌症中的作用具有重要意义。
BubR1 is an essential component of the spindle assembly checkpoint (SAC) during mitosis where it functions to prevent anaphase onset to ensure proper chromosome alignment and kinetochore-microtubule attachment. Loss or mutation of BubR1 results in aneuploidy that precedes various potential pathologies, including cancer and mosaic variegated aneuploidy (MVA). BubR1 is also progressively downregulated with age and has been shown to be directly involved in the aging process through suppression of cellular senescence. Post-translational modifications, including but not limited to phosphorylation, acetylation, and ubiquitination, play a critical role in the temporal and spatial regulation of BubR1 function. In this review, we discuss the currently characterized post-translational modifications to BubR1, the enzymes involved, and the biological consequences to BubR1 functionality and implications in diseases associated with BubR1. Understanding the molecular mechanisms promoting these modifications and their roles in regulating BubR1 is important for our current understanding and future studies of BubR1 in maintaining genomic integrity as well as in aging and cancer.
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影响因子：
64.8
作者：
Cahill, DP;Lengauer, C;Vogelstein, B
通讯作者：
Vogelstein, B
影响因子：
10.5
作者：
Elowe, Sabine;Huemmer, Stefan;Nigg, Erich A.
通讯作者：
Nigg, Erich A.
影响因子：
18.2
作者：
Campisi J
通讯作者：
Campisi J
DOI：
10.1083/jcb.202002020
发表时间：
2020-12-07
期刊：
The Journal of cell biology
影响因子：
--
作者：
Cordeiro MH;Smith RJ;Saurin AT
通讯作者：
Saurin AT
影响因子：
3.3
作者：
Beaufils, Sylvie;Grossmann, J. Guenter;Bolanos-Garcia, Victor M.
通讯作者：
Bolanos-Garcia, Victor M.