Relationships of H. pylori infection and its related gastroduodenal morbidity with metabolic syndrome: a large cross-sectional study.
Relationships of H. pylori infection and its related gastroduodenal morbidity with metabolic syndrome: a large cross-sectional study.
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DOI：
10.1038/s41598-018-22198-9
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发表时间：
2018-03-06
影响因子：
4.6
通讯作者：
Muhsen K
中科院分区：
文献类型：
--
作者：
Refaeli R;Chodick G;Haj S;Goren S;Shalev V;Muhsen K
The few published studies on the relationship between Helicobacter pylori infection and metabolic homeostasis were relatively small and yielded inconsistent results. We examined the prevalence of metabolic syndrome in relation to H. pylori infection and its symptoms in a large and unselected population. Coded data from the computerised database of a large health maintenance organisation in Israel were accessed for 147,936 individuals 25–95 years of age who performed the urea breath test during 2002–2012. The classification of metabolic syndrome followed a modified definition of the international diabetes federation. Prevalences of H. pylori infection and metabolic syndrome were 52.0% and 11.4% respectively. H. pylori infected patients had increased likelihood of metabolic syndrome: adjusted odds ratio (aOR) 1.15 (95% confidence intervals (CI) 1.10–1.19), as did patients with gastric ulcer: aOR 1.15 (95% CI 1.03–1.28) vs patients without these conditions. Duodenal ulcer was associated with metabolic syndrome only in persons aged 25–34 years: aOR 1.59 (95% CI 1.19-2.13), but not in older persons (P = 0.001 for heterogeneity). In conclusion, the likelihood of metabolic syndrome appeared significantly increased in relation to H. pylori infection and gastric and duodenal ulcers. These findings suggest that H. pylori long-term gastric inflammation might play a role in metabolic homeostasis.
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幽门螺杆菌感染和消化性疾病与糖尿病性梅洛蒂斯的关联：一项基于人群的大型研究的结果。
影响因子：
3.7
作者：
Haj S;Chodick G;Refaeli R;Goren S;Shalev V;Muhsen K
通讯作者：
Muhsen K
影响因子：
4.4
作者：
Chen, Tsung-Po;Hung, Hui-Fang;Yang, Kuen-Cheh
通讯作者：
Yang, Kuen-Cheh
影响因子：
--
作者：
LEAN, MEJ;HAN, TS;MORRISON, CE
通讯作者：
MORRISON, CE
DOI：
10.1038/oby.2003.168
发表时间：
2003-10-01
期刊：
OBESITY RESEARCH
影响因子：
--
作者：
Ford, ES;Mokdad, AH;Giles, WH
通讯作者：
Giles, WH
影响因子：
4.4
作者：
Franceschi, Francesco;Gasbarrini, Antonio;Kountouras, Jannis
通讯作者：
Kountouras, Jannis