Short-term, high-fat overfeeding impairs glycaemic control but does not alter gut hormone responses to a mixed meal tolerance test in healthy, normal-weight individuals.
Short-term, high-fat overfeeding impairs glycaemic control but does not alter gut hormone responses to a mixed meal tolerance test in healthy, normal-weight individuals.
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短期高脂肪过量喂养会损害血糖控制，但不会改变健康、正常体重个体对混合膳食耐受性测试的肠道激素反应。
DOI：
10.1017/s0007114516004475
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发表时间：
2017
期刊：
影响因子：
--
通讯作者：
C. Hulston
中科院分区：
文献类型：
--
作者：
S. Parry;Jennifer R. Smith;Talitha R B Corbett;R. Woods;C. Hulston
Obesity is undoubtedly caused by a chronic positive energy balance. However, the early metabolic and hormonal responses to overeating are poorly described. This study determined glycaemic control and selected gut hormone responses to nutrient intake before and after 7 d of high-fat overfeeding. Nine healthy individuals (five males, four females) performed a mixed meal tolerance test (MTT) before and after consuming a high-fat (65 %), high-energy (+50 %) diet for 7 d. Measurements of plasma glucose, NEFA, acylated ghrelin, glucagon-like peptide-1 (GLP-1), gastric inhibitory polypeptide (GIP) and serum insulin were taken before (fasting) and at 30-min intervals throughout the 180-min MTT (postprandial). Body mass increased by 0·79 (sem 0·14) kg after high-fat overfeeding (P<0·0001), and BMI increased by 0·27 (sem 0·05) kg/m2 (P=0·002). High-fat overfeeding also resulted in an 11·6 % increase in postprandial glucose AUC (P=0·007) and a 25·9 % increase in postprandial insulin AUC (P=0·005). Acylated ghrelin, GLP-1 and GIP responses to the MTT were all unaffected by the high-fat, high-energy diet. These findings demonstrate that even brief periods of overeating are sufficient to disrupt glycaemic control. However, as the postprandial orexigenic (ghrelin) and anorexigenic/insulintropic (GLP-1 and GIP) hormone responses were unaffected by the diet intervention, it appears that these hormones are resistant to short-term changes in energy balance, and that they do not play a role in the rapid reduction in glycaemic control.
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影响因子：
5.8
作者：
McLaughlin, T;Abbasi, F;Cummings, DE
通讯作者：
Cummings, DE
影响因子：
7.7
作者：
Cummings, DE;Purnell, JQ;Weigle, DS
通讯作者：
Weigle, DS
早晨的生长素释放肽浓度不受短期过度喂养的影响，并且不能预测人类的随意食物摄入量。
DOI：
10.3945/ajcn.2008.27011
发表时间：
2009
期刊：
The American journal of clinical nutrition
影响因子：
--
作者：
Votruba,SusanneB;Kirchner,Henriette;Tschop,Matthias;Salbe,ArlineD;Krakoff,Jonathan
通讯作者：
Krakoff,Jonathan
影响因子：
158.5
作者：
Cummings, DE;Weigle, DS;Purnell, JQ
通讯作者：
Purnell, JQ
影响因子：
7.1
作者：
MIFFLIN, MD;STJEOR, ST;KOH, YO
通讯作者：
KOH, YO