Higher population-based incidence rates of triple-negative breast cancer among young African-American women : Implications for breast cancer screening recommendations.
Higher population-based incidence rates of triple-negative breast cancer among young African-American women : Implications for breast cancer screening recommendations.
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DOI：
10.1002/cncr.25862
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发表时间：
2011-06-15
期刊：
影响因子：
6.2
通讯作者：
Newman, Lisa A.
中科院分区：
文献类型：
--
作者：
Amirikia, Kathryn C.;Mills, Paul;Bush, Jason;Newman, Lisa A.
与美国白人女性相比，非裔美国人乳腺癌负担的差异是有据可查的。最近出现了关于适合年龄的乳房X光检查指南的争议，这些监测建议可能会影响未来乳腺癌的差异。我们的目标是在基于人群的肿瘤登记中评估特定年龄的乳腺癌分期分布和三阴性乳腺癌(TNBC)的发病率。我们分析了加州癌症登记处(CCR)1988-2006年间诊断的乳腺癌。结果按年龄和种族/民族分层，美国白人被确定为非西班牙裔白人(NHW)，非裔美国人被确定为非西班牙裔黑人(NHB)。分析乳腺癌分期分布和TNBC发生率。总共评估了375,761例浸润性乳腺癌(包括276,938例NHW和21,681例NHB)，NHB和西班牙裔倾向于比NHW年轻(中位数分别为57岁、54岁和岁)。与NHB和西班牙裔相比，NHW的终生发病率更高，但对于44岁以下的女性，NHB的发病率最高。NHB的III、IV期发病率较高，各年龄段的TNBC发病率均较高。基于人口的数据表明，与美国白人相比，非洲裔美国女性患乳腺癌的阶段分布更晚期，而且TNBC的发病率更高。这些模式在40-49岁的女性和老年女性中都能观察到，这表明早期发现乳腺癌的乳房X光检查将对年轻的非裔美国女性特别相关。
Differences in the breast cancer burden of African American compared with White American women are well-documented. Recent controversies have emerged regarding age-appropriate mammographic screening guidelines, and these surveillance recommendations may influence future breast cancer disparities. Our goal was to evaluate age-specific breast cancer stage distributions and incidence rates of triple-negative breast cancer (TNBC) in a population-based tumor registry. We analyzed California Cancer Registry (CCR) breast cancers diagnosed 1988 – 2006. Results were stratified by age and race/ethnicity, with White Americans identified as Non-Hispanic Whites (NHW) and African Americans as Non-Hispanic Blacks (NHB). Breast cancer stage distributions and TNBC incidence rates were also analyzed. A total of 375,761 invasive breast cancers were evaluated (including 276,938 in NHW and 21,681 in NHB) NHB and Hispanics tended to be younger than NHW (median ages 57; 54; and 64 years, respectively). Lifetime incidence rates were higher for NHW compared to NHB and Hispanics, but for women younger than 44 years incidence was highest among NHB. NHB also had higher incidence rates of Stage III and IV disease, and higher incidence of TNBC in all age categories. Population-based data demonstrate that African American women have a more advanced stage distribution for breast cancer compared to White Americans, and higher incidence rates for TNBC. These patterns are observed for women age 40–49 years as well as older women, and suggest that mammographic screening for early detection of breast cancer will be particularly relevant for younger African American women.
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影响因子：
2.1
作者：
Parise, Carol A.;Bauer, Katrina R.;Caggiano, Vincent
通讯作者：
Caggiano, Vincent
影响因子：
3.7
作者：
Bird, P. A.;Hill, A. G.;Houssami, N.
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Houssami, N.
影响因子：
5.9
作者：
Ko, Eun Sook;Lee, Byung Hee;Lee, Sang-Ah
通讯作者：
Lee, Sang-Ah
影响因子：
3.8
作者：
Lund, Mary Jo;Trivers, Katrina F.;Eley, J. William
通讯作者：
Eley, J. William
影响因子：
3.8
作者：
Millikan, Robert C.;Newman, Beth;Perou, Charles M.
通讯作者：
Perou, Charles M.