Changes in Tumor Volumes and Spatial Locations Relative to Normal Tissues During Cervical Cancer Radiotherapy Assessed by Cone Beam Computed Tomography.
Changes in Tumor Volumes and Spatial Locations Relative to Normal Tissues During Cervical Cancer Radiotherapy Assessed by Cone Beam Computed Tomography.
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DOI：
10.1177/1533034616685942
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发表时间：
2017-04
影响因子：
2.8
通讯作者：
Chen K
中科院分区：
文献类型：
--
作者：
Chen W;Bai P;Pan J;Xu Y;Chen K
目的：应用锥束CT评价宫颈癌治疗过程中肿瘤及其周围器官体积和空间位置的变化。16例宫颈癌患者在化疗和/或放疗期间接受了调强放疗和离线锥束计算机断层扫描。肿瘤大体体积(GTV-T)和临床靶区体积(CTV)在计划CT和每周锥束CT图像上被勾画出来，并用体积差法和Dice相似系数评价体积和空间位置的变化。治疗前(0f)GTV-T为79.62 cm~3，外照射结束时为20.86 cm~3。临床靶区体积从672.59~608.26 cm~3，子宫体积(CTV-T)从83.72 cm~3~80.23 cm~3。不同组间GTV-T、CTV-T差异有统计学意义(P<；.001)，但临床靶区体积差异无统计学意义(P>；.05)。GTV-T、CTV-T、临床靶区的平均体积变化百分比分别为23.05%~70.85%、4.71%~6.78%、5.84%~9.59%，组间差异有统计学意义(P<；0.05)。GTV-T的Dice相似系数在放疗过程中呈下降趋势(P<；.001)。此外，GTV-T在不同组间有显著差异(P<；.001)，且GTV-T的变化与放疗有关(P<；.001)。GTV-T与危险器官的体积变化率(DV)与Dice相似系数呈负相关(r<；0；P<；0.05)。GTV-T的体积、体积变化率和Dice相似系数均与放射治疗的增加相关。宫颈癌放射治疗过程中肿瘤消退和空间位置发生显著变化。为了提高宫颈癌的治疗精度，需要采用适应性放射治疗方法。
To assess changes in the volumes and spatial locations of tumors and surrounding organs by cone beam computed tomography during treatment for cervical cancer. Sixteen patients with cervical cancer had intensity-modulated radiotherapy and off-line cone beam computed tomography during chemotherapy and/or radiation therapy. The gross tumor volume (GTV-T) and clinical target volumes (CTVs) were contoured on the planning computed tomography and weekly cone beam computed tomography image, and changes in volumes and spatial locations were evaluated using the volume difference method and Dice similarity coefficients. The GTV-T was 79.62 cm3 at prior treatment (0f) and then 20.86 cm3 at the end of external-beam chemoradiation. The clinical target volume changed slightly from 672.59 cm3 to 608.26 cm3, and the uterine volume (CTV-T) changed slightly from 83.72 cm3 to 80.23 cm3. There were significant differences in GTV-T and CTV-T among the different groups (P < .001), but the clinical target volume was not significantly different in volume (P > .05). The mean percent volume changes ranged from 23.05% to 70.85% for GTV-T, 4.71% to 6.78% for CTV-T, and 5.84% to 9.59% for clinical target volume, and the groups were significantly different (P < .05). The Dice similarity coefficient of GTV-T decreased during the course of radiation therapy (P < .001). In addition, there were significant differences in GTV-T among different groups (P < .001), and changes in GTV-T correlated with the radiotherapy (P < .001). There was a negative correlation between volume change rate (DV) and Dice similarity coefficient in the GTV-T and organs at risk (r < 0; P < .05). The volume, volume change rate, and Dice similarity coefficient of GTV-T were all correlated with increase in radiation treatment. Significant variations in tumor regression and spatial location occurred during radiotherapy for cervical cancer. Adaptive radiotherapy approaches are needed to improve the treatment accuracy for cervical cancer.
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影响因子：
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