Serum Sex Hormone Binding Globulin Concentration as a Predictor of Ovarian Response During Controlled Ovarian Hyperstimulation.
Serum Sex Hormone Binding Globulin Concentration as a Predictor of Ovarian Response During Controlled Ovarian Hyperstimulation.
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血清性激素结合球蛋白浓度作为受控卵巢过度刺激期间卵巢反应的预测因子
DOI：
10.3389/fmed.2021.719818
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发表时间：
2021
影响因子：
3.9
通讯作者：
Du Y
中科院分区：
文献类型：
--
作者：
Zhai J;Li S;Zhu Y;Sun Y;Chen ZJ;Du Y
目的：不孕症患者血清性激素结合球蛋白(SHBG)浓度与卵泡总数呈正相关。然而，在控制性超排卵(COH)中血清SHBG浓度与卵巢反应之间的关系，以及患有和不患有多囊卵巢综合征(PCOS)的妇女之间的这种关系是否不同，目前尚不清楚。方法：研究队列包括120例接受体外受精的患者，其中非多囊卵巢综合征患者60例，多囊卵巢综合征患者60例。在COH周期中每2-3天从每个参与者身上采集一次血清样本。通过测定血清SHBG及其他性激素水平，探讨PCOS患者血清SHBG水平与卵巢反应的关系。结果：非PCOS患者血清SHBG水平与卵巢反应呈正相关，PCOS患者血清SHBG水平与卵巢反应无相关性。结论：血清SHBG水平可作为无PCOS患者COH中卵巢反应的临床预测指标。
Purpose: Serum concentrations of sex hormone binding globulin (SHBG), a glycated homodimeric plasma transport protein, correlate positively with the total number of follicles in women with infertility. However, the relationship between serum SHBG concentrations and the ovarian response during controlled ovarian hyperstimulation (COH) and whether this relationship differs between women with and without polycystic ovary syndrome (PCOS) remains unclear. Methods: The study cohort included 120 participants (60 non-PCOS and 60 PCOS) undergoing in vitro fertilization. Serum samples were collected from each participant every 2–3 days during the COH cycle. The concentrations of serum SHBG and other sex hormones were determined to investigate the relationship between serum SHBG concentrations and the ovarian response in women with and without PCOS. Results: We found that the serum SHBG concentration was positively correlated with the ovarian response in non-PCOS patients but not in PCOS patients. Conclusion: The serum SHBG concentration may be clinically useful as a predictor of the ovarian response during COH in patients without PCOS.
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影响因子：
4.8
作者：
Simo, Rafael;Saez-Lopez, Cristina;Selva, David M.
通讯作者：
Selva, David M.
影响因子：
1.3
作者：
Calzada, Mireya;Lopez, Natividad;Torres, Alberto M.
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Torres, Alberto M.
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作者：
Cordeiro, Fernanda Bertuccez;Cataldi, Thais Regiani;Lo Turco, Edson Guimaraes
通讯作者：
Lo Turco, Edson Guimaraes
影响因子：
2
作者：
Lin, KC;Sun, MJ
通讯作者：
Sun, MJ