Cardioprotective signaling to mitochondria.
Cardioprotective signaling to mitochondria.
复制标题
对线粒体的心脏保护信号传导。
DOI：
10.1016/j.yjmcc.2008.11.019
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发表时间：
2009-06
影响因子：
5
通讯作者：
Dos Santos, Pierre
中科院分区：
文献类型：
--
作者：
Garlid, Keith D.;Costa, Alexandre D. T.;Quinlan, Casey L.;Pierre, Sandrine V.;Dos Santos, Pierre
关键词：
Mitochondria are central players in the pathophysiology of ischemia-reperfusion. Activation of plasma membrane G-coupled receptors or the Na, K-ATPase trigger cytosolic signaling pathways that result in cardioprotection. Our working hypothesis is that the occupied receptors migrate to caveolae, where signaling enzymes are scaffolded into signalosomes that bud off the plasma membrane and migrate to mitochondria. The signalosome-mitochondria interaction then initiates intramitochondrial signaling by opening the mitochondrial ATP-sensitive K+ channel (mitoKATP). MitoKATP opening causes an increase in ROS production, which activates mitochondrial protein kinase C epsilon (PKCε), which inhibits the mitochondrial permeability transition (MPT), thus decreasing cell death. We review the experimental findings that bear on these hypotheses and other modes of protection involving mitochondria.
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DOI：
10.1124/jpet.105.092023
发表时间：
2006-02-01
影响因子：
3.5
作者：
Bian, JS;Yong, QC;Moore, PK
通讯作者：
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影响因子：
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作者：
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影响因子：
20.1
作者：
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通讯作者：
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影响因子：
4.8
作者：
Costa, Alexandre D. T.;Jakob, Regina;Garlid, Keith D.
通讯作者：
Garlid, Keith D.
DOI：
10.1124/jpet.104.074476
发表时间：
2005-02-01
影响因子：
3.5
作者：
Cao, CM;Xia, Q;Wong, TM
通讯作者：
Wong, TM