The corneal subbasal nerve plexus and thickness of the retinal layers in pediatric type 1 diabetes and matched controls.
The corneal subbasal nerve plexus and thickness of the retinal layers in pediatric type 1 diabetes and matched controls.
复制标题
DOI：
10.1038/s41598-017-18284-z
复制
发表时间：
2018-01-08
影响因子：
4.6
通讯作者：
Fischer DC
中科院分区：
文献类型：
--
作者：
Götze A;von Keyserlingk S;Peschel S;Jacoby U;Schreiver C;Köhler B;Allgeier S;Winter K;Röhlig M;Jünemann A;Guthoff R;Stachs O;Fischer DC
视网膜的光学相干断层扫描（OCT）和基底下神经丛（SBP）的角膜共焦激光扫描显微镜（CLSM）是用于量化1型糖尿病（T1 DM）患者眼部神经退行性变化的无创技术。在成人T1 DM患者中，这些变化几乎不与T1 DM相关。相反，年龄和/或生活方式相关的合并症必须被视为假定的混杂变量。因此，我们研究了没有糖尿病视网膜疾病、神经病变、血管病变或肾病临床体征的儿童T1 DM患者（n = 28; 14.2 ± 2.51岁;病程：5.39 ± 4.16岁），并将我们的结果与健康对照组（n = 46; 14.8 ± 1.89岁）的结果进行了比较。收缩压的特点是平均长度，厚度和曲折的神经纤维，以及分支和连接点的数量。OCT用于确定视网膜的总厚度（ALL）和视网膜各层的厚度。这两种方法均显示了早期神经退行性变化的体征，例如，中央周围环处的不同视网膜层变薄和儿童T1 DM患者中已经存在的角膜神经纤维缩短。迫切需要仪器和算法的标准化，以实现不同群体之间的统一比较，并定义在临床环境中引入的规范值。
Optical coherence tomography (OCT) of the retina and corneal confocal laser scanning microscopy (CLSM) of the subbasal nerve plexus (SBP) are noninvasive techniques for quantification of the ocular neurodegenerative changes in individuals with type 1 diabetes mellitus (T1DM). In adult T1DM patients these changes are hardly related to T1DM only. Instead, ageing and/or lifestyle associated comorbidities have to be considered as putative confounding variables. Therefore, we investigated pediatric T1DM patients (n = 28; 14.2 ± 2.51 y; duration of disease: 5.39 ± 4.16 y) without clinical signs of diabetic retina disease, neuropathy, vasculopathy or nephropathy and compared our findings with those obtained in healthy controls (n = 46; 14.8 ± 1.89 y). The SBP was characterized by the averaged length, thickness, and tortuosity of nerve fibers as well as the number of branching and connecting points. OCT was used to determine the total thickness of the retina (ALL) and the thickness of each retinal layer. Both methods revealed signs of early neurodegenerative changes, e.g. thinning of distinct retinal layers at the pericentral ring and shortening of corneal nerve fibers that are already present in pediatric T1DM patients. Standardization of instruments and algorithms are urgently required to enable uniform comparison between different groups and define normative values to introduce in the clinical setting.
登录
查看更多内容
影响因子：
5.1
作者：
Pritchard, Nicola;Edwards, Katie;Efron, Nathan
通讯作者：
Efron, Nathan
影响因子：
4.4
作者：
Allgeier, Stephan;Zhivov, Andrey;Stachs, Oliver
通讯作者：
Stachs, Oliver
影响因子：
4.4
作者：
Dehghani, Cirous;Pritchard, Nicola;Efron, Nathan
通讯作者：
Efron, Nathan
影响因子：
1.9
作者：
Edwards, Katie;Pritchard, Nicola;Efron, Nathan
通讯作者：
Efron, Nathan
影响因子：
8.1
作者：
Bressler, Susan B.;Edwards, Allison R.;Chalam, Kakarla V.;Bressler, Neil M.;Glassman, Adam R.;Jaffe, Glenn J.;Melia, Michele;Saggau, David D.;Plous, Oren Z.
通讯作者：
Plous, Oren Z.