Does the healing of the esophageal mucosa improve the function of the esophageal submucosal and salivary glands?
Does the healing of the esophageal mucosa improve the function of the esophageal submucosal and salivary glands?
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食管粘膜的愈合是否会改善食管粘膜下和唾液腺的功能？
DOI：
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发表时间：
2016
影响因子：
5.2
通讯作者：
J. Sarosiek
中科院分区：
文献类型：
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作者：
J. Sarosiek
食管上皮前屏障包括食管粘膜下腺和唾液腺的分泌物成分。我们证明，在反流性食管炎（RE）患者中，食管表皮生长因子（EGF）的腔内释放显著减少。食管前列腺素E2 （PGE2）的腔内释放率显著高于对照组，在RE愈合后显著下降，食管粘蛋白分泌也显著下降；然而，雷贝拉唑治疗后，这一比例明显增加。RE患者唾液EGF和碳酸氢盐分泌率明显低于对照组。我们已经证明，咀嚼无味的副膜，在临床场景中可以用无糖口香糖代替，导致唾液保护因子，如碳酸氢盐、粘蛋白、蛋白质、EGF和PGE2的分泌率显著增加。我们的数据清楚地表明，食管粘膜的形态或结构不仅与食管粘膜下腺的分泌功能有关，而且与唾液腺的分泌功能有关。在临床场景中应用咀嚼刺激也可能具有一些治疗潜力。
The esophageal pre‐epithelial barrier encompasses components of secretions from both the esophageal submucosal and salivary glands. We demonstrated, in patients with reflux esophagitis (RE), significantly diminished luminal release of esophageal epidermal growth factor (EGF). The rate of luminal release of esophageal prostaglandin E2 (PGE2) was significantly higher compared with controls and significantly declined after healing of RE. Patients with RE also exhibited significant declines in esophageal mucin secretion; however, after healing of RE with rabeprazole, this rate increased significantly. The rate of salivary EGF and bicarbonate secretion in patients with RE was significantly lower than in controls. We have demonstrated that mastication of tasteless parafilm, which could be substituted with sugarless chewing gum in the clinical scenario, resulted in profound and significant increases in the rate of secretion of salivary protective factors, such as bicarbonate, mucin, protein, EGF, and PGE2, in patients with RE. Our data clearly indicate that there is a relationship between the form or the structure of the esophageal mucosa and the secretory function of not only the esophageal submucosal glands but also the salivary glands. Application of masticatory stimulation in a clinical scenario may also have some therapeutic potential.
影响因子：
3.2
作者：
Orlando, Roy C.
通讯作者：
Orlando, Roy C.