Human V6: functional characterisation and localisation.
Human V6: functional characterisation and localisation.
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DOI：
10.1371/journal.pone.0047685
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发表时间：
2012
期刊：
影响因子：
3.7
通讯作者：
Smith AT
中科院分区：
文献类型：
--
作者：
Cardin V;Sherrington R;Hemsworth L;Smith AT
顶枕沟中的人类视觉区V6被认为在提取用于监测和引导自运动（自运动）的光流中具有重要作用，因为当与以下相比时，其对自运动兼容光流的响应不同：（a）相干但自运动不兼容的流（Cardin & Smith，2010），和（B）非相干运动（Pitzalis等人，2010年）。然而，目前尚不清楚V6是否对自我运动不相容的全局运动的响应比对非相干运动的响应更强烈。这不仅与确定V6的功能特性有关，而且也是为了选择最佳刺激，以便用fMRI准确地定位V6。视网膜定位是困难的，需要一个简单，可靠的方法。我们进行了一个事件相关的3 T fMRI实验，参与者观看了一个点的显示：a）遵循一个随时间变化的光流轨迹在一个单一的，自我运动兼容（EC）显示; B）形成一个自我运动不兼容（EI）的3×3阵列的光流补丁;或c）随机移动（RM）。来自V6的结果显示响应幅度的排序：EC > EI > RM。邻近地区V3 A和V7对EC的反应比RM更强烈，但对EC和EI的反应大致相同。我们的研究结果表明，虽然V6可能有一个普遍的作用，在提取的全球运动，在明显的对比，邻近的运动领域，它是特别关注与编码EC刺激。他们提出了两种定位V6的策略：（1）对比EC和EI;或（2）对比EC和RM，这更敏感，但存在包括来自相邻区域的体素的风险，这些体素也显示出EC > RM偏好。
Human visual area V6, in the parieto-occipital sulcus, is thought to have an important role in the extraction of optic flow for the monitoring and guidance of self-motion (egomotion) because it responds differentially to egomotion-compatible optic flow when compared to: (a) coherent but egomotion-incompatible flow (Cardin & Smith, 2010), and (b) incoherent motion (Pitzalis et al., 2010). It is not clear, however, whether V6 responds more strongly to egomotion-incompatible global motion than to incoherent motion. This is relevant not only for determining the functional properties of V6, but also in order to choose optimal stimuli for localising V6 accurately with fMRI. Localisation with retinotopic mapping is difficult and there is a need for a simple, reliable method. We conducted an event-related 3T fMRI experiment in which participants viewed a display of dots which either: a) followed a time-varying optic flow trajectory in a single, egomotion-compatible (EC) display; b) formed an egomotion-incompatible (EI) 3×3 array of optic flow patches; or c) moved randomly (RM). Results from V6 show an ordering of response magnitudes: EC > EI > RM. Neighbouring areas V3A and V7 responded more strongly to EC than to RM, but about equally to EC and EI. Our results suggest that although V6 may have a general role in the extraction of global motion, in clear contrast to neighbouring motion areas it is especially concerned with encoding EC stimuli. They suggest two strategies for localising V6: (1) contrasting EC and EI; or (2) contrasting EC and RM, which is more sensitive but carries a risk of including voxels from neighbouring regions that also show a EC > RM preference.
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