Regulation from within: the cytoskeleton in transmembrane signaling.
Regulation from within: the cytoskeleton in transmembrane signaling.
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DOI：
10.1016/j.tcb.2012.07.006
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发表时间：
2012-10
影响因子：
19
通讯作者：
Grinstein, Sergio
中科院分区：
文献类型：
--
作者：
Jaqaman, Khuloud;Grinstein, Sergio
有越来越多的证据表明，质膜是高度动态和组织复杂的方式。皮质细胞骨架被证明是一个特别重要的质浆组织调节剂，调节膜中蛋白质和脂质的流动性，促进它们的分离并影响它们的聚集。这种组织在受体介导的信号传导中起着关键作用，特别是在免疫受体的情况下，它们需要侧向聚集才能激活。基于最近的研究进展，我们讨论了皮层细胞骨架调节膜动力学和组织的结构和机制，以及免疫受体的不均匀分布及其自我关联如何影响激活和信号传导。
There is mounting evidence that the plasma membrane is highly dynamic and organized in a complex manner. The cortical cytoskeleton is proving to be a particularly important regulator of plasmalemmal organization, modulating the mobility of proteins and lipids in the membrane, facilitating their segregation and influencing their clustering. This organization plays a critical role in receptor-mediated signaling, especially in the case of immunoreceptors, which require lateral clustering for their activation. Based on recent developments, we discuss the structures and mechanisms whereby the cortical cytoskeleton regulates membrane dynamics and organization, and how the non-uniform distribution of immunoreceptors and their self-association may affect activation and signaling.
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