Clinical characteristics and beta cell function in Chinese patients with newly diagnosed type 2 diabetes mellitus with different levels of serum triglyceride.
Clinical characteristics and beta cell function in Chinese patients with newly diagnosed type 2 diabetes mellitus with different levels of serum triglyceride.
复制标题
中国新诊断不同血清甘油三酯水平的2型糖尿病患者的临床特征和β细胞功能。
DOI：
10.1186/s12902-015-0018-1
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发表时间：
2015-04-29
影响因子：
2.7
通讯作者：
Hu Y
中科院分区：
文献类型：
--
作者：
Zheng S;Zhou H;Han T;Li Y;Zhang Y;Liu W;Hu Y
目的探讨不同血清甘油三酯（TG）水平的初诊未用药2型糖尿病（T2 DM）患者的临床特点及胰岛β细胞功能。入选624例初诊T2 DM患者，根据血清TG水平分为不同组。所有患者均接受口服葡萄糖耐量试验和胰岛素释放试验。比较不同组间的人口统计学数据、血脂谱、血糖水平和胰岛素谱。采用基础胰岛素分泌功能指数（β细胞功能指数稳态模型评估，HOMA-β）、改良β细胞功能指数（MBCI）、葡萄糖处置指数（DI）和早期胰岛素分泌功能指数（胰岛素生成指数，IGI）评价β细胞功能。与TG正常的T2 DM患者相比，新诊断的T2 DM伴高甘油三酯血症患者更年轻、肥胖，血脂、血糖和胰岛素水平更差。不同TG水平的初诊T2 DM患者早期胰岛素分泌无差异。基础β细胞功能（HOMA-β和MBCI）最初随着TG水平的升高而沿着升高，然后随着TG水平的进一步升高而降低。低TG组胰岛素敏感性较高，高TG组胰岛素敏感性较低。高甘油三酯血症对中国新诊断2型糖尿病患者临床特征和β细胞功能的影响更好的血脂异常管理可能在一定程度上降低脂毒性的影响，从而改善新诊断的T2 DM患者的葡萄糖稳态。本文的在线版本（doi：10.1186/s12902-015-0018-1）包含补充材料，可供授权用户使用。
To explore clinical characteristics and beta cell function in Chinese patients with newly diagnosed drug naive type 2 diabetes mellitus (T2DM) with different levels of serum triglyceride (TG). Patients with newly diagnosed T2DM (n = 624) were enrolled and divided into different groups according to levels of serum TG. All patients underwent oral glucose tolerance tests and insulin releasing tests. Demographic data, lipid profiles, glucose levels, and insulin profiles were compared between different groups. Basic insulin secretion function index (homeostasis model assessment for beta cell function index, HOMA-β), modified beta cell function index (MBCI), glucose disposition indices (DI), and early insulin secretion function index (insulinogenic index, IGI) were used to evaluate the beta cell function. Patients of newly diagnosed T2DM with hypertriglyceridemia were younger, fatter and had worse lipid profiles, glucose profiles, and high insulin levels than those with normal TG. There is no difference in early phase insulin secretion among groups of newly diagnosed T2DM patients with different TG levels. The basal beta cell function (HOMA-β and MBCI) initially increased along rising TG levels and then decreased as the TG levels rose further. The insulin sensitivity was relatively high in patients with a low level of TG and low with a high level of TG. Hypertriglyceridemia influences clinical characteristics and β cell function of Chinese patients with newly diagnosed T2DM. A better management of dyslipidemia may, to some extent, reduce the effect of lipotoxicity, thereby improving glucose homeostasis in patients with newly diagnosed T2DM. The online version of this article (doi:10.1186/s12902-015-0018-1) contains supplementary material, which is available to authorized users.
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影响因子：
4.3
作者：
Ma Y;Wang Y;Huang Q;Ren Q;Chen S;Zhang A;Zhao L;Zhen Q;Peng Y
通讯作者：
Peng Y
影响因子：
120.7
作者：
Elam, MB;Hunninghake, DB;Brinton, EA
通讯作者：
Brinton, EA
影响因子：
2.4
作者：
Reaven, Gerald M.
通讯作者：
Reaven, Gerald M.
DOI：
10.1152/ajpendo.00053.2009
发表时间：
2009-09-01
影响因子：
5.1
作者：
Alberti, Avra;Karamessinis, Panagiotis;Charonis, Aristidis
通讯作者：
Charonis, Aristidis
影响因子：
158.5
作者：
HAFFNER, SM;STERN, MP;PATTERSON, JK
通讯作者：
PATTERSON, JK