Systematic Review and Methodological Considerations for the Use of Single Prolonged Stress and Fear Extinction Retention in Rodents.
Systematic Review and Methodological Considerations for the Use of Single Prolonged Stress and Fear Extinction Retention in Rodents.
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啮齿类动物单次延长应激和恐惧消退保留的系统评价和方法学考虑。
DOI：
10.3389/fnbeh.2021.652636
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发表时间：
2021
影响因子：
3
通讯作者：
Haas M
中科院分区：
文献类型：
--
作者：
Ferland-Beckham C;Chaby LE;Daskalakis NP;Knox D;Liberzon I;Lim MM;McIntyre C;Perrine SA;Risbrough VB;Sabban EL;Jeromin A;Haas M
创伤后应激障碍（PTSD）是一种心理健康状况，由经历或目睹可怕的事件引发，可能导致终身负担，增加死亡率和不良健康后果。然而，二十年来没有新的治疗方法进入市场。因此，筛选PTSD的潜在干预措施是高度优先事项。动物模型通常作为一个关键的转化工具，将新的治疗方法从实验室带到床边。然而，一些人类临床试验结果与临床前动物有效性结果缺乏一致性，导致对如何进行动物研究和建立翻译有效性的方法提出质疑。因此，我们进行了系统的审查，以确定方法的差异，在研究中应用了一个突出的动物模型的创伤样压力，单一的长期压力（SPS）。SPS模型已被用来评估无数的PTSD相关的结果，包括灭绝保留。暴露于SPS的啮齿动物表现出消退保留缺陷，这是在患有PTSD的人类中鉴定的表型，其中恐惧记忆在恐惧记忆消退后异常保留。目前的系统评价检查方法的变化，在所有阶段的SPS范式，以及战略的行为编码，数据处理，统计方法，和描述的数据。讨论了这些领域内的关键挑战和变化来源的解决方案。为了应对SPS研究中的方法学差异，召集了一个专家小组，以产生方法学考虑，指导研究人员应用SPS和评估消光保留作为PTSD样表型的测试。这些指南中的许多适用于所有啮齿动物范例，这些范例是为了模拟创伤效应或与创伤后应激障碍相关的习得性恐惧过程而开发的，而不限于SPS。优化临床前模型应用对于提高临床前研究结果的可重复性和转化有效性至关重要，并且应该对所有临床前精神病学研究模型进行优化。
Posttraumatic stress disorder (PTSD) is a mental health condition triggered by experiencing or witnessing a terrifying event that can lead to lifelong burden that increases mortality and adverse health outcomes. Yet, no new treatments have reached the market in two decades. Thus, screening potential interventions for PTSD is of high priority. Animal models often serve as a critical translational tool to bring new therapeutics from bench to bedside. However, the lack of concordance of some human clinical trial outcomes with preclinical animal efficacy findings has led to a questioning of the methods of how animal studies are conducted and translational validity established. Thus, we conducted a systematic review to determine methodological variability in studies that applied a prominent animal model of trauma-like stress, single prolonged stress (SPS). The SPS model has been utilized to evaluate a myriad of PTSD-relevant outcomes including extinction retention. Rodents exposed to SPS express an extinction retention deficit, a phenotype identified in humans with PTSD, in which fear memory is aberrantly retained after fear memory extinction. The current systematic review examines methodological variation across all phases of the SPS paradigm, as well as strategies for behavioral coding, data processing, statistical approach, and the depiction of data. Solutions for key challenges and sources of variation within these domains are discussed. In response to methodological variation in SPS studies, an expert panel was convened to generate methodological considerations to guide researchers in the application of SPS and the evaluation of extinction retention as a test for a PTSD-like phenotype. Many of these guidelines are applicable to all rodent paradigms developed to model trauma effects or learned fear processes relevant to PTSD, and not limited to SPS. Efforts toward optimizing preclinical model application are essential for enhancing the reproducibility and translational validity of preclinical findings, and should be conducted for all preclinical psychiatric research models.
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DOI：
10.1037/h0077224
发表时间：
1976-01-01
期刊：
JOURNAL OF COMPARATIVE AND PHYSIOLOGICAL PSYCHOLOGY
影响因子：
--
作者：
BRONSTEIN, PM;HIRSCH, SM
通讯作者：
HIRSCH, SM
影响因子：
1.9
作者：
Artal, P;de Tejada, PH;Green, DG
通讯作者：
Green, DG
影响因子：
3
作者：
Chaby, Lauren E.;Karavidha, Klevis;Liberzon, Israel
通讯作者：
Liberzon, Israel
影响因子：
2.7
作者：
Arai A;Hirota Y;Miyase N;Miyata S;Young LJ;Osako Y;Yuri K;Mitsui S
通讯作者：
Mitsui S
影响因子：
--
作者：
Chang, Chun-hui;Knapska, Ewelina;Orsini, Caitlin A;Rabinak, Christine A;Zimmerman, Joshua M;Maren, Stephen
通讯作者：
Maren, Stephen