Prediction of wall stress and oxygen flow in patient-specific abdominal aortic aneurysms: the role of intraluminal thrombus
Prediction of wall stress and oxygen flow in patient-specific abdominal aortic aneurysms: the role of intraluminal thrombus
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患者特异性腹主动脉瘤壁应力和氧流量的预测：腔内血栓的作用
DOI：
10.1007/s10237-022-01618-w
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发表时间：
2022
影响因子：
3.5
通讯作者：
Zakerzadeh, Rana
中科院分区：
文献类型：
--
作者：
Throop, Alexis;Bukac, Martina;Zakerzadeh, Rana
本研究探讨腔内血栓(ILT)在腹主动脉瘤(AAA)中的生物力学作用。ILT在AAA中的含义在文献中一直存在争议。先前的研究表明，ILT通过降低壁应力提供生物力学优势，而其他研究则认为ILT与抑制氧转运和诱导主动脉壁变薄有关。因此，我们试图探索ILT、机械应力和不同几何形状的具有不同ILT形态的患者特定动脉瘤中的氧流量之间的联系。目的是研究ILT在多大程度上影响与破裂相关的动脉瘤壁应力的预测，以及衡量组织氧缺乏的氧浓度。考虑了三种特定于患者的AAA几何结构，并为每个患者创建了两个模型，一个有ILT，一个没有ILT，以评估ILT的影响。采用流固耦合的方法来耦合血液流动、壁面变形和氧气质量传输。给出了血流动力学模式、壁应力测量和动脉壁内氧气计量的结果。虽然ILT被发现可以减少壁应力，但模拟证实ILT显著减少了组织内的氧气运输，导致壁面缺氧。
In this study, the biomechanical role of intraluminal thrombus (ILT) in an abdominal aortic aneurysm (AAA) is investigated. The implications of ILT in AAA are controversial in literature. Previous studies have demonstrated that ILT provides a biomechanical advantage by decreasing wall stress, whereas other studies have associated ILT with inhibiting oxygen transport and inducing aortic wall weakening. Therefore, we sought to explore the connection between ILT, mechanical stresses, and oxygen flow in different geometries of patient-specific aneurysms with varying ILT morphologies. The objective is to investigate the extent to which ILT influences the prediction of aneurysmal wall stresses that are associated with rupture, as well as oxygen concentrations to measure tissue oxygen deprivation. Three patient-specific AAA geometries are considered, and two models, one with ILT and one without ILT, are created for each patient to assess the effect of ILT presence. A fluid–structure interaction approach is used to couple the blood flow, wall deformation, and oxygen mass transport. Results are presented for hemodynamics patterns, wall stress measures, and oxygen metrics within the arterial wall. While ILT is found to reduce wall stress, simulations confirm that ILT decreases oxygen transport within the tissue significantly, leading to wall hypoxia.
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DOI：
--
发表时间：
2000
期刊：
Cardiovascular surgery
影响因子：
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DOI：
--
发表时间：
2010
期刊：
影响因子：
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影响因子：
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DOI：
10.1016/s1078-5884(98)80031-2
发表时间：
1998-04-01
影响因子：
5.7
作者：
Di Martino, E;Mantero, S;Fumero, R
通讯作者：
Fumero, R