Diagnosis and monitoring of abdominal aortic aneurysm: current status and future prospects.

Diagnosis and monitoring of abdominal aortic aneurysm: current status and future prospects.
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DOI:
10.1016/j.cpcardiol.2010.08.004
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发表时间:
2010-10
影响因子:
4.2
通讯作者:
Golledge, Jonathan
Golledge, Jonathan
中科院分区:
医学3区
文献类型:
--
作者:
Moxon, Joseph V.;Parr, Adam;Emeto, Theophilus I.;Walker, Philip;Norman, Paul E.;Golledge, Jonathan

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腹主动脉瘤(AAA)仍然是老年男性发病和死亡的重要原因,预计患病率将随着全球人口老龄化而增加。AAA通常无症状,在缺乏常规筛查的情况下,在影像学评估不相关的医学疾患时,诊断通常是偶然的。在缺乏批准的诊断和预后标志物的情况下,通过医学影像学保守监测AAAs,直到主动脉直径接近50-55mm并进行手术修复。目前,人们对鉴别AAA诊断和预后价值的分子标记物非常感兴趣。在这里,我们概述了AAA管理的现行指南,并讨论了目前用于鉴别改进的诊断和预后标记物的现代科学技术。
Abdominal aortic aneurysm (AAA) remains an important cause of morbidity and mortality in elderly men, and prevalence is predicted to increase in parallel with a global ageing population. AAA is commonly asymptomatic, and in the absence of routine screening, diagnosis is usually incidental when imaging to assess unrelated medical complaints. In the absence of approved diagnostic and prognostic markers, AAAs are monitored conservatively via medical imaging until aortic diameter approaches 50–55mm and surgical repair is performed. There is currently significant interest in identifying molecular markers of diagnostic and prognostic value for AAA. Here we outline the current guidelines for AAA management, and discuss modern scientific techniques currently employed to identify improved diagnostic and prognostic markers.
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