miRNA dysregulation is an emerging modulator of genomic instability.
miRNA dysregulation is an emerging modulator of genomic instability.
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DOI：
10.1016/j.semcancer.2021.05.004
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发表时间：
2021-11
影响因子：
14.5
通讯作者：
States JC
中科院分区：
文献类型：
--
作者：
Ferragut Cardoso AP;Banerjee M;Nail AN;Lykoudi A;States JC
基因组不稳定性包括基因组内的一系列遗传改变，导致肿瘤异质性和耐药性。这是大多数癌细胞公认的特征。基因组不稳定的诱导是由于DNA损伤监测机制、有丝分裂检查点和DNA修复机制的缺陷。遗传变异的积累最终使细胞走向恶性转化。最近的研究表明，mirna是介导基因组不稳定性的关键因素。mirna是在大多数体细胞组织中表达的一类小rna，是表观基因组的一部分。重要的是，在许多癌症中，miRNA表达失调。因此，本综述探讨了miRNA失调作为诱导基因组不稳定和随后致癌的因果步骤的作用。我们特别关注评估miRNA(s)和特定亚型基因组不稳定性或已知的基因组不稳定性模式的机制研究。此外，我们还提供了该领域现有知识差距的见解以及解决这些差距的可能方法。
Genomic instability consists of a range of genetic alterations within the genome that contributes to tumor heterogeneity and drug resistance. It is a well-established characteristic of most cancer cells. Genome instability induction results from defects in DNA damage surveillance mechanisms, mitotic checkpoints and DNA repair machinery. Accumulation of genetic alterations ultimately sets cells towards malignant transformation. Recent studies suggest that miRNAs are key players in mediating genome instability. miRNAs are a class of small RNAs expressed in most somatic tissues and are part of the epigenome. Importantly, in many cancers, miRNA expression is dysregulated. Consequently, this review examines the role of miRNA dysregulation as a causal step for induction of genome instability and subsequent carcinogenesis. We focus specifically on mechanistic studies assessing miRNA(s) and specific subtypes of genome instability or known modes of genome instability. In addition, we provide insight on the existing knowledge gaps within the field and possible ways to address them.
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影响因子：
19
作者：
Ceccaldi R;Rondinelli B;D'Andrea AD
通讯作者：
D'Andrea AD
影响因子：
4.6
作者：
Bonneville R;Krook MA;Kautto EA;Miya J;Wing MR;Chen HZ;Reeser JW;Yu L;Roychowdhury S
通讯作者：
Roychowdhury S
影响因子：
3.3
作者：
Carvalhal S;Ribeiro SA;Arocena M;Kasciukovic T;Temme A;Koehler K;Huebner A;Griffis ER
通讯作者：
Griffis ER
影响因子：
3.8
作者：
Browning, Cynthia L.;Qin, Qin;Wise, John Pierce, Sr.
通讯作者：
Wise, John Pierce, Sr.
影响因子：
3.7
作者：
Anand, Preetha;Kunnumakara, Ajaikumar B.;Sundaram, Chitra;Harikumar, Kuzhuvelil B.;Tharakan, Sheeja T.;Lai, Oiki S.;Sung, Bokyung;Aggarwal, Bharat B.
通讯作者：
Aggarwal, Bharat B.