Derivation of the multiply-branched ergot alkaloid pathway of fungi.
Derivation of the multiply-branched ergot alkaloid pathway of fungi.
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DOI：
10.1111/1751-7915.14214
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发表时间：
2023-04
影响因子：
5.7
通讯作者：
中科院分区：
文献类型：
--
作者：
麦角生物碱是真菌特化代谢产物的大家族，其作为农业中的毒素和作为强效药物的基础是重要的。来自几个谱系和不同生态位的真菌从麦角生物碱途径的几个分支中的至少一个产生麦角生物碱。不同分支的生化和遗传基础已经建立，并在此简要概述。几个途径分支在真菌谱系和生态位之间重叠，表明麦角生物碱活性在不同环境和条件下对真菌有益。了解途径的每个分支中多个基因的功能，使研究人员能够解析公共数据库中丰富的基因组序列数据，以评估以前未探索的真菌的麦角生物碱生物合成能力。此外，涉及各个分支的基因的表征为麦角生物碱的生物技术操作提供了机会和资源，用于实验和药物开发。麦角生物碱是真菌特化代谢产物的大家族，其作为农业中的毒素和作为强效药物的基础是重要的。来自几个谱系和不同生态位的真菌从麦角生物碱途径的几个分支中的至少一个产生麦角生物碱。不同分支的生化和遗传基础已经建立，并在此简要概述。
Ergot alkaloids are a large family of fungal specialized metabolites that are important as toxins in agriculture and as the foundation of powerful pharmaceuticals. Fungi from several lineages and diverse ecological niches produce ergot alkaloids from at least one of several branches of the ergot alkaloid pathway. The biochemical and genetic bases for the different branches have been established and are summarized briefly herein. Several pathway branches overlap among fungal lineages and ecological niches, indicating activities of ergot alkaloids benefit fungi in different environments and conditions. Understanding the functions of the multiple genes in each branch of the pathway allows researchers to parse the abundant genomic sequence data available in public databases in order to assess the ergot alkaloid biosynthesis capacity of previously unexplored fungi. Moreover, the characterization of the genes involved in the various branches provides opportunities and resources for the biotechnological manipulation of ergot alkaloids for experimentation and pharmaceutical development. Ergot alkaloids are a large family of fungal specialized metabolites that are important as toxins in agriculture and as the foundation of powerful pharmaceuticals. Fungi from several lineages and diverse ecological niches produce ergot alkaloids from at least one of several branches of the ergot alkaloid pathway. The biochemical and genetic bases for the different branches have been established and are summarized briefly herein.
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影响因子：
15
作者：
Cheng, Johnathan Z.;Coyle, Christine M.;Panaccione, Daniel G.;O'Connor, Sarah E.
通讯作者：
O'Connor, Sarah E.
影响因子：
2.5
作者：
Bilovol, Yulia;Panaccione, Daniel G.
通讯作者：
Panaccione, Daniel G.
影响因子：
4.2
作者：
Gerhards N;Neubauer L;Tudzynski P;Li SM
通讯作者：
Li SM
影响因子：
4.5
作者：
Gao Q;Jin K;Ying SH;Zhang Y;Xiao G;Shang Y;Duan Z;Hu X;Xie XQ;Zhou G;Peng G;Luo Z;Huang W;Wang B;Fang W;Wang S;Zhong Y;Ma LJ;St Leger RJ;Zhao GP;Pei Y;Feng MG;Xia Y;Wang C
通讯作者：
Wang C
影响因子：
2.3
作者：
Beaulieu, Wesley T.;Panaccione, Daniel G.;Clay, Keith
通讯作者：
Clay, Keith