Innate lymphoid cell disturbance with increase in ILC1 in systemic lupus erythematosus.
Innate lymphoid cell disturbance with increase in ILC1 in systemic lupus erythematosus.
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系统性红斑狼疮中先天性淋巴细胞紊乱伴 ILC1 增加
DOI：
10.1016/j.clim.2019.03.008
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发表时间：
2019-05
期刊：
影响因子：
--
通讯作者：
Fu SM
中科院分区：
文献类型：
--
作者：
Guo C;Zhou M;Zhao S;Huang Y;Wang S;Fu R;Li M;Zhang T;Gaskin F;Yang N;Fu SM
先天性淋巴样细胞（intrinsic lymphoid cell，ILC）是一组在健康和疾病状态下具有多种重要细胞功能的效应细胞。与健康对照组相比，SLE患者的循环ILC增加。SLE患者ILC 1的比例显著升高，ILC 2的比例显著降低，而ILC 3的比例在中重度活动的SLE患者中显著降低。SLE患者血清IL-12、IL-18、IL-25、IL-33、IL-23、IL-1β和IFN-γ水平明显升高。IL-12、IL-18和IL-1β与SLEDAI显著相关，而IFN-γ与SLEDAI无显著相关性。成功的治疗迅速减少了它们，并使ILC亚群恢复正常。除了ILC 1数量增加外，SLE患者中约80%的ILC 1为IFN-γ合成阳性。来自SLE患者的血浆显示出在诱导ILC 1方面是有效的。因此，增加循环ILC 1可能有助于通过安装1型免疫反应的SLE的发病机制。
The innate lymphoid cell (ILC) is a group of effector cells with diverse important cellular functions in both health and disease states. In comparison with healthy controls, there were increases in circulating ILC in SLE patients. The proportion of ILC1 significantly increased with significant decreases of ILC2 in SLE patients and ILC3 in SLE patients with moderate to severe activity. IL-12, IL-18, IL-25, IL-33, IL-23, IL-1β and IFN-γ were significantly increased in SLE patients. Moreover, IL-12, IL-18 and IL-1β but not IFN-γ correlated significantly with SLEDAI. Successful treatments rapidly reduced them and with certain normalization of the ILC subsets. In addition to increases in ILC1 numbers, ~ 80% of the ILC1 in SLE patients were positive for synthesis of IFN-γ. Plasma from SLE patients were shown to be potent in inducing ILC1. Thus, increased circulating ILC1 might contribute to the pathogenesis of SLE through mounting type 1 immune response.
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影响因子：
27.4
作者：
Munroe ME;Lu R;Zhao YD;Fife DA;Robertson JM;Guthridge JM;Niewold TB;Tsokos GC;Keith MP;Harley JB;James JA
通讯作者：
James JA
影响因子：
5.4
作者：
Heufler, C;Koch, F;Schuler, G
通讯作者：
Schuler, G
影响因子：
6.5
作者：
Teunissen, Marcel B. M.;Munneke, J. Marius;Mjosberg, Jenny
通讯作者：
Mjosberg, Jenny
影响因子：
30.5
作者：
Bernink, Jochem H.;Peters, Charlotte P.;Spits, Hergen
通讯作者：
Spits, Hergen
影响因子：
13.3
作者：
Schmidt, Tilman;Paust, Hans-Joachim;Panzer, Ulf
通讯作者：
Panzer, Ulf