Anaplastic Thyroid Cancer in Sicily: The Role of Environmental Characteristics.
Anaplastic Thyroid Cancer in Sicily: The Role of Environmental Characteristics.
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DOI：
10.3389/fendo.2017.00277
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发表时间：
2017
影响因子：
5.2
通讯作者：
Pellegriti G
中科院分区：
文献类型：
--
作者：
Tavarelli M;Malandrino P;Vigneri P;Richiusa P;Maniglia A;Violi MA;Sapuppo G;Vella V;Dardanoni G;Vigneri R;Pellegriti G
间变性甲状腺癌（ATC）是一种罕见但极具侵袭性的甲状腺癌，占甲状腺癌特异性死亡率的30-40%。我们分析了西西里的ATC特征和存活率，以评估环境因素的可能影响。为此，比较了西西里城市/农村和工业、碘缺乏和火山与对照区的ATC发病率数据以及西西里和美国的ATC数据。使用Sicilian Register of Thyroid Cancer（SRTC）数据库，对西西里不同地区的发病率、年龄、性别、肿瘤大小和组织型、甲状腺外扩散、分期以及与既存分化型甲状腺癌（DTC）共存的情况进行了评价，并与美国的监测流行病学和最终结果数据进行了比较。2002-2009年期间，在西西里发现了43个ATC。在我们的系列中，只有诊断时年龄<70岁（p = 0.01），与DTC共存（p = 0.027）和肿瘤大小≤6 cm（p = 0.012）是单变量分析中生存率增加的重要因素（多变量分析中只有年龄）。城市与农村、缺碘地区和工业区与对照区的ATC发病率无差异。相比之下，在西西里的火山区，DTC的发病率是岛上其他地区的两倍，ATC的发病率也增加了。西西里的ATC数据与美国同期报告的数据相似，但6个月和12个月的总生存率较小。在西西里和美国观测到类似的ATC数据（具有不同的遗传背景和生活方式）和西西里火山地区ATC发病率的增加与乳头状甲状腺癌发病率的增加是一致的，这与偶然的额外突变的可能性是一致的，在细胞复制增加的背景下，如DCT，是ATC的主要原因，而不是遗传背景和/或直接的环境影响。
Anaplastic thyroid cancer (ATC) is a rare but extremely aggressive cancer of the thyroid, contributing up to 30–40% of thyroid cancer-specific mortality. We analyzed ATC characteristics and survival rates in Sicily to evaluate the possible influence of environmental factors. With this aim, data regarding ATC incidences in urban/rural and industrial, iodine-deficient, and volcanic vs control areas were compared in Sicily as well as ATC data from Sicily and USA. Using the Sicilian Register of Thyroid Cancer (SRTC) database incidence, age, gender, tumor size and histotype, extrathyroidal extension, stage, and coexistence with pre-existing differentiated thyroid cancer (DTC) were evaluated in different areas of Sicily and also compared with Surveillance Epidemiology and End Results data in USA. Forty-three ATCs were identified in Sicily in the period 2002–2009. In our series only age <70 years at diagnosis (p = 0.01), coexistence with DTC (p = 0.027) and tumor size ≤6 cm (p = 0.012) were significant factors for increased survival at univariate analysis (only age at multivariate analysis). No difference in ATC incidence was found in urban vs rural areas and in iodine-deficient and industrial vs control areas. By contrast, in the volcanic area of Sicily, where DTC incidence is doubled relative to the rest of the island, also ATC incidence was increased. ATC data in Sicily were similar to those reported in the same period in the USA where overall survival rate at 6 and 12 months, however, was smaller. The similar ATC data observed in Sicily and USA (having different genetic background and lifestyle) and the increased ATC incidence in the volcanic area of Sicily paralleling the increased incidence of papillary thyroid cancer are compatible with the possibility that casual additional mutations, more frequent in a background of increased cell replication like DCT, are the major causes of ATC rather than genetic background and/or direct environmental influences.
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影响因子：
--
作者：
Nagaiah G;Hossain A;Mooney CJ;Parmentier J;Remick SC
通讯作者：
Remick SC
DOI：
10.1056/nejmoa1502309
发表时间：
2015-08-20
期刊：
The New England journal of medicine
影响因子：
--
作者：
Hyman DM;Puzanov I;Subbiah V;Faris JE;Chau I;Blay JY;Wolf J;Raje NS;Diamond EL;Hollebecque A;Gervais R;Elez-Fernandez ME;Italiano A;Hofheinz RD;Hidalgo M;Chan E;Schuler M;Lasserre SF;Makrutzki M;Sirzen F;Veronese ML;Tabernero J;Baselga J
通讯作者：
Baselga J
影响因子：
5.8
作者：
Enomoto, Keisuke;Zhu, Xuguang;Cheng, Sheue-yann
通讯作者：
Cheng, Sheue-yann
影响因子：
2.7
作者：
Lin, Hung-Yun;Tang, Heng-Yuan;Davis, Faith B.
通讯作者：
Davis, Faith B.
影响因子：
5.8
作者：
Moleti, Mariacarla;Lo Presti, Vincenzo Pio;Vermiglio, Francesco
通讯作者：
Vermiglio, Francesco