Smoking cessation and bronchial epithelial remodelling in COPD: a cross-sectional study.
Smoking cessation and bronchial epithelial remodelling in COPD: a cross-sectional study.
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DOI：
10.1186/1465-9921-8-85
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发表时间：
2007-11-26
影响因子：
5.8
通讯作者：
GLUCOLD Study Group
中科院分区：
文献类型：
--
作者：
Lapperre TS;Sont JK;van Schadewijk A;Gosman MM;Postma DS;Bajema IM;Timens W;Mauad T;Hiemstra PS;GLUCOLD Study Group
慢性阻塞性肺疾病（COPD）与支气管上皮变化相关，包括鳞状细胞化生和杯状细胞增生。这些特征部分归因于表皮生长因子受体（EGFR）的激活。尽管戒烟可以减轻慢性阻塞性肺病患者的呼吸道症状和肺功能下降，但炎症仍然存在。我们确定了患有慢性阻塞性肺病的当前吸烟者和戒烟者的支气管活检中的上皮增殖和成分，及其与戒烟持续时间的关系。对 114 名 COPD 患者进行了横断面研究：99 名男性/15 名女性，年龄 62 ± 8 岁，中位 42 包年，无皮质类固醇，当前吸烟者 (n = 72) 或戒烟者 (n = 42，中位戒烟持续时间 3.5 年)，支气管扩张剂后 FEV1 预测为 63 ± 9%。在支气管活检的完整上皮中测量鳞状细胞化生 (%)、杯状细胞 (PAS/Alcian Blue+) 面积 (%)、增殖 (Ki-67+) 细胞数 (/mm 基底膜) 和 EGFR 表达 (%)。与目前患有 COPD 的吸烟者相比，患有 COPD 的戒烟者的上皮鳞状细胞化生、增殖细胞数量和杯状细胞面积减少的趋势显着减少（分别为 p = 0.025、p = 0.001、p = 0.081），但 EGFR 表达无显着差异。短期戒烟者（<3.5 年）和当前吸烟者的上皮特征没有差异。长期戒烟者（≥3.5 年）的杯状细胞面积比当前吸烟者和短期戒烟者要小（中位数：分别为 7.9% vs. 14.4%，p = 0.005；7.9% vs. 13.5%，p = 0.008），增殖细胞数量也比当前吸烟者少（2.8% vs. 18.6%，p < 0.001）。患有慢性阻塞性肺病的戒烟者比当前吸烟者的支气管上皮重塑较少，只有在长期戒烟（>3.5年）后才能观察到。 NCT00158847
Chronic Obstructive Pulmonary Disease (COPD) is associated with bronchial epithelial changes, including squamous cell metaplasia and goblet cell hyperplasia. These features are partially attributed to activation of the epidermal growth factor receptor (EGFR). Whereas smoking cessation reduces respiratory symptoms and lung function decline in COPD, inflammation persists. We determined epithelial proliferation and composition in bronchial biopsies from current and ex-smokers with COPD, and its relation to duration of smoking cessation. 114 COPD patients were studied cross-sectionally: 99 males/15 females, age 62 ± 8 years, median 42 pack-years, no corticosteroids, current (n = 72) or ex-smokers (n = 42, median cessation duration 3.5 years), postbronchodilator FEV1 63 ± 9% predicted. Squamous cell metaplasia (%), goblet cell (PAS/Alcian Blue+) area (%), proliferating (Ki-67+) cell numbers (/mm basement membrane), and EGFR expression (%) were measured in intact epithelium of bronchial biopsies. Ex-smokers with COPD had significantly less epithelial squamous cell metaplasia, proliferating cell numbers, and a trend towards reduced goblet cell area than current smokers with COPD (p = 0.025, p = 0.001, p = 0.081, respectively), but no significant difference in EGFR expression. Epithelial features were not different between short-term quitters (<3.5 years) and current smokers. Long-term quitters (≥3.5 years) had less goblet cell area than both current smokers and short-term quitters (medians: 7.9% vs. 14.4%, p = 0.005; 7.9% vs. 13.5%, p = 0.008; respectively), and less proliferating cell numbers than current smokers (2.8% vs. 18.6%, p < 0.001). Ex-smokers with COPD had less bronchial epithelial remodelling than current smokers, which was only observed after long-term smoking cessation (>3.5 years). NCT00158847
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影响因子：
6.4
作者：
Caramori, G;Di Gregorio, C;Papi, A
通讯作者：
Papi, A
影响因子：
10
作者：
O'Donnell, RA;Richter, A;Wilson, SJ
通讯作者：
Wilson, SJ
影响因子：
24.3
作者：
PRESCOTT, E;LANGE, P;VESTBO, J
通讯作者：
VESTBO, J
影响因子：
10
作者：
Lapperre, TS;Postma, DS;Mauad, T
通讯作者：
Mauad, T
DOI：
10.1093/jnci/93.14.1081
发表时间：
2001-07-18
期刊：
JOURNAL OF THE NATIONAL CANCER INSTITUTE
影响因子：
--
作者：
Lee, JJ;Liu, D;Hittelman, WN
通讯作者：
Hittelman, WN