An electrophysiological study of the medial prefrontal cortical projection to the nucleus of the solitary tract in rat
An electrophysiological study of the medial prefrontal cortical projection to the nucleus of the solitary tract in rat
复制标题
大鼠内侧前额皮质投射至孤束核的电生理学研究
DOI：
--
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发表时间：
1996
影响因子：
2
通讯作者：
A. Verberne
中科院分区：
文献类型：
--
作者：
N. Owens;A. Verberne
内侧前额叶皮质（MPFC）被描述为一个“内脏”皮质区，因为自主神经效应，如降压反应，可以从这个区域。介导这些降压反应的中枢回路可能包括从MPFC到孤束核（NTS）的投射。在MPFC细胞外记录神经元，并测试NTS的逆向（AD）激活。这些都测试了（1）恒定的尖峰潜伏期，（2）跟随超过200 Hz的高频刺激的能力，和（3）在可能的情况下，刺激诱发的尖峰与自发尖峰或谷氨酸离子电渗应用诱发的尖峰的碰撞。在研究的34个细胞中，所有细胞都具有恒定的AD潜伏期（30±1 ms，范围16-46 ms）;它们遵循高达354±19 Hz的高频刺激，只有7个细胞自发活动（范围1-19 spikes/s）。AD激活的阈值刺激强度为102±9 μA（n=34，范围8-200 μA）。深度阈值曲线（n=7）显示最小阈值AD激活电流，对应于背侧和腹侧分区的NTS。AD潜伏期的小位移被发现在深度阈值曲线，提示轴突分支。记录网站的分析表明，NTS投射MPFC神经元主要发现在边缘和腹侧边缘前区的MPFC。这些结果表明，有一个人口的神经元在MPFC项目，并可能终止于NTS。这种投射可能部分介导MPFC刺激的心血管反应。
The medial prefrontal cortex (MPFC) has been described as a “visceromotor” cortical area, since autonomic effects such as depressor responses may be elicited from this area. The central circuitry which mediates these depressor responses may include a projection from the MPFC to the nucleus of the solitary tract (NTS). Neurones were recorded extracellularly in the MPFC and were tested for antidromic (AD) activation from the NTS. These were all tested for (1) constant spike latency, (2) ability to follow high-frequency stimulation to more than 200 Hz, and (3) where possible, collision of stimulation-evoked spike with spontaneous spike or spikes evoked by iontophoretic application of glutamate. Of the 34 cells studied, all had constant AD latency (30±1 ms, range 16–46 ms); they followed high-frequency stimulation up to 354±19 Hz, and only seven cells were spontaneously active (range 1–19 spikes/s). The threshold stimulation intensity for AD activation was 102±9 μA (n=34, range 8–200 μA). Depth-threshold curves (n=7) showed minimum-threshold AD activation currents that corresponded to the dorsal and ventral sub-divisions of the NTS. Small shifts in AD latency were found in the depth-threshold curves, suggesting axonal branching. Analysis of recording sites showed that NTS-projecting MPFC neurones were predominantly found in the infralimbic and ventral prelimbic regions of the MPFC. These findings indicate that there is a population of neurones in the MPFC that projects to, and probably terminates within, the NTS. It is possible that this projection may, in part, mediate the cardiovascular response to MPFC stimulation.
延髓头侧腹外侧神经元介导躯体升压反射。
DOI：
10.1152/ajpregu.1989.256.2.r448
发表时间：
1989
期刊：
The American journal of physiology
影响因子：
--
作者：
Stornetta,RL;Morrison,SF;Ruggiero,DA;Reis,DJ
通讯作者：
Reis,DJ
大鼠髓质压力敏感神经元和 C1 细胞的升络。
DOI：
10.1152/ajpregu.1990.258.4.r1051
发表时间：
1990
期刊：
The American journal of physiology
影响因子：
--
作者：
Haselton,JR;Guyenet,PG
通讯作者：
Guyenet,PG
DOI：
10.1016/0165-1838(82)90089-3
发表时间：
1982
期刊：
Journal of the autonomic nervous system
影响因子：
--
作者：
Gebber,GL;Barman,SM
通讯作者：
Barman,SM