Near-InfraRed PhotoImmunoTherapy (NIR-PIT) for the local control of solid cancers: Challenges and potentials for human applications.
Near-InfraRed PhotoImmunoTherapy (NIR-PIT) for the local control of solid cancers: Challenges and potentials for human applications.
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DOI：
10.1016/j.critrevonc.2021.103325
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发表时间：
2021-05
期刊：
影响因子：
--
通讯作者：
Giuliani S
中科院分区：
文献类型：
--
作者：
Paraboschi I;Turnock S;Kramer-Marek G;Musleh L;Barisa M;Anderson J;Giuliani S
近红外光免疫疗法（NIR-PIT）是一种很有前途的技术，旨在选择性地杀死癌细胞，而不损害宿主组织和器官。它通过光敏剂（例如NIR酞菁染料IRDye 700DX）和癌症靶向部分（例如单克隆抗体，moAb）之间的化学缀合来实现。NIR-PIT在各种癌症中的临床前和临床研究集中在一起，突出了关键的未回答的研究问题。近红外光免疫疗法（NIR-PIT）是通过光敏剂（例如NIR酞菁染料IRDye 700DX）和癌症靶向部分（例如单克隆抗体，moAb）之间的化学缀合实现的新型癌症靶向治疗。缀合物的体内递送通过结合细胞表面受体或抗原而导致在肿瘤细胞表面的积累。在部署聚焦NIR光后，缀合物的照射导致快速的靶向细胞死亡。然而，产生细胞毒性作用的作用机制尚未完全了解。在此，我们汇集了来自各种癌症的临床前和临床研究的NIR-PIT的当前知识，突出了关键的未回答的研究问题。此外，我们还讨论了如何使用这种新的治疗方案来增强实体癌的局部控制。
Near-InfraRed PhotoImmunoTherapy (NIR-PIT) is a promising technique aiming to selectively kill cancer cells while leaving the host tissues and organs undamaged. It is effected by a chemical conjugation between a photosensitiser (e.g. the NIR phthalocyanine dye IRDye700DX) and a cancer-targeting moiety (e.g. a monoclonal antibody, moAb). Preclinical and clinical studies of NIR-PIT in a variety of cancers are here brought together highlighting the key unanswered research questions. Near-InfraRed PhotoImmunoTherapy (NIR-PIT) is a novel cancer-targeted treatment effected by a chemical conjugation between a photosensitiser (e.g. the NIR phthalocyanine dye IRDye700DX) and a cancer-targeting moiety (e.g. a monoclonal antibody, moAb). Delivery of a conjugate in vivo leads to accumulation at the tumour cell surface by binding to cell surface receptors or antigens. Upon deployment of focal NIR-light, irradiation of the conjugate results in a rapid, targeted cell death. However, the mechanisms of action to produce the cytotoxic effects have yet to be fully understood. Herein, we bring together the current knowledge of NIR-PIT from preclinical and clinical studies in a variety of cancers highlighting the key unanswered research questions. Furthermore, we discuss how to enhance the local control of solid cancers using this novel treatment regimen.
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影响因子：
12.4
作者：
Jing H;Weidensteiner C;Reichardt W;Gaedicke S;Zhu X;Grosu AL;Kobayashi H;Niedermann G
通讯作者：
Niedermann G
DOI：
10.1073/pnas.0906549106
发表时间：
2009-08-18
影响因子：
11.1
作者：
Chan, Keith Syson;Espinosa, Inigo;Weissman, Irving L.
通讯作者：
Weissman, Irving L.
影响因子：
50.3
作者：
Chen, Ruihuan;Nishimura, Merry C.;Phillips, Heidi S.
通讯作者：
Phillips, Heidi S.
影响因子：
16.6
作者：
Anderson ED;Gorka AP;Schnermann MJ
通讯作者：
Schnermann MJ
影响因子：
3.3
作者：
Chaux, Alcides;Cohen, Julie S.;Schultz, Luciana;Albadine, Roula;Jadallah, Sana;Murphy, Kathleen M.;Sharma, Rajni;Schoenberg, Mark P.;Netto, George J.
通讯作者：
Netto, George J.