Incidence of chronic lymphocytic leukemia and high-count monoclonal B-cell lymphocytosis using the 2008 guidelines.
Incidence of chronic lymphocytic leukemia and high-count monoclonal B-cell lymphocytosis using the 2008 guidelines.
复制标题
使用2008年指南，慢性淋巴细胞性白血病和高规模单克隆B细胞淋巴细胞增多的发生率。
DOI：
10.1002/cncr.28690
复制
发表时间：
2014-07-01
期刊：
影响因子：
6.2
通讯作者：
Slager, Susan L.
中科院分区：
文献类型：
--
作者：
Call, Timothy G.;Norman, Aaron D.;Hanson, Curtis A.;Achenbach, Sara J.;Kay, Neil E.;Zent, Clive S.;Ding, Wei;Cerhan, James R.;Rabe, Kari G.;Vachon, Celine M.;Hallberg, Emily J.;Shanafelt, Tait D.;Slager, Susan L.
关键词：
The National Cancer Institute Working Group (NCI-WG 96) guidelines classified individuals having a B-cell clone with CLL immunophenotype as CLL if the absolute lymphocyte count (ALC) was ≥5 × 109/L. 2008 International Workshop on CLL guidelines (IWCLL 2008) classified as CLL if the absolute B-cell count is ≥5 × 109/L or as monoclonal B-cell lymphocytosis (MBL) if the absolute B-cell count is <5 × 109/L. This study of Olmsted County, Minnesota, assessed effects of these changes on incidence rates and presentation from 2000–2010. Using diagnostic indices available through the Rochester Epidemiology Project and the Mayo CLL database, we identified all newly diagnosed CLL and high count MBL cases from 2000–2010. Age and sex specific incidence rates were determined. With NCI-WG 96 criteria, there were 115 cases of CLL and 8 cases of MBL. Using IWCLL 2008 classification, there were 79 cases of CLL and 40 cases of MBL. Rai stage distribution (low, intermediate, high) using NCI-WG 96 was 60.9%, 33.9% and 5.2% compared to 43.0%, 49.4%, and 7.6% under IWCLL 2008 criteria. The age- and sex-adjusted incidence rate (per 100,000) for CLL and MBL were 10.0 and 0.66 using NCI-WG 96 versus 6.8 and 3.5 using IWCLL 2008. Median time to treatment (TTT) using NCI-WG 96 was 9.2 years versus 6.5 years with IWCLL 2008 Use of the IWCLL 2008 guidelines reduce the incidence of CLL, alter the distribution of initial Rai stage at diagnosis and shorten median TTT.
登录
查看更多内容
影响因子：
45.3
作者：
Shanafelt, Tait D.;Kay, Neil E.;Hanson, Curtis A.
通讯作者：
Hanson, Curtis A.
影响因子：
6.2
作者：
Shanafelt, Tait D.;Rabe, Kari G.;Call, Timothy G.
通讯作者：
Call, Timothy G.
影响因子：
158.5
作者：
Rawstron, Andy C.;Bennett, Fiona L.;Hillmen, Peter
通讯作者：
Hillmen, Peter
影响因子：
20.3
作者：
Cheson, BD;Bennett, JM;Rai, KR
通讯作者：
Rai, KR
影响因子：
11.4
作者：
Moreira, J.;Rabe, K. G.;Shanafelt, T. D.
通讯作者：
Shanafelt, T. D.