PPL2ab neurons restore sexual responses in aged Drosophila males through dopamine.
PPL2ab neurons restore sexual responses in aged Drosophila males through dopamine.
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DOI：
10.1038/ncomms8490
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发表时间：
2015-06-30
影响因子：
16.6
通讯作者：
Fu, Tsai-Feng
中科院分区：
文献类型：
--
作者：
Kuo, Shu-Yun;Wu, Chia-Lin;Hsieh, Min-Yen;Lin, Chen-Ta;Wen, Rong-Kun;Chen, Lien-Cheng;Chen, Yu-Hui;Yu, Yhu-Wei;Wang, Horng-Dar;Su, Yi-Ju;Lin, Chun-Ju;Yang, Cian-Yi;Guan, Hsien-Yu;Wang, Pei-Yu;Lan, Tsuo-Hung;Fu, Tsai-Feng
男性的性欲通常会随着年龄的增长而下降。然而，我们对这种现象的神经生物学基础的理解受到我们对控制男性性欲的大脑回路和神经通路的知识的限制。许多跨物种的研究表明，多巴胺（DA）影响性欲。在这里，我们使用遗传工具和行为分析，以确定一个新的DA神经元的子集，调节与年龄相关的男性在果蝇的求爱活动。我们发现，增加DA水平的一个子集的细胞中的PPL2ab神经元簇是必要的，足够的增加持续求爱在年轻和老年雄性苍蝇。我们的研究结果表明，防止PPL 2ab神经元中与年龄相关的DA水平下降会减少雄性果蝇的求偶行为。这些结果可能为破译雄性果蝇大脑中涉及性动机的回路提供基础。 我们目前缺乏对男性性欲随年龄增长而下降的神经生物学基础的详细了解。在这里，作者证明了恢复果蝇大脑中特定神经元簇中受损的多巴胺能信号可以增加衰老雄性果蝇的性行为。
Male sexual desire typically declines with ageing. However, our understanding of the neurobiological basis for this phenomenon is limited by our knowledge of the brain circuitry and neuronal pathways controlling male sexual desire. A number of studies across species suggest that dopamine (DA) affects sexual desire. Here we use genetic tools and behavioural assays to identify a novel subset of DA neurons that regulate age-associated male courtship activity in Drosophila. We find that increasing DA levels in a subset of cells in the PPL2ab neuronal cluster is necessary and sufficient for increased sustained courtship in both young and aged male flies. Our results indicate that preventing the age-related decline in DA levels in PPL2ab neurons alleviates diminished courtship behaviours in male Drosophila. These results may provide the foundation for deciphering the circuitry involved in sexual motivation in the male Drosophila brain. We currently lack a detailed understanding of the neurobiological basis for the decline of male sexual desire with age. Here the authors demonstrate that restoring impaired dopaminergic signalling in a specific cluster of neurons in the Drosophila brain increases sexual behaviour in ageing male flies.
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影响因子：
5.3
作者：
ECONOMOS, AC;MIQUEL, J;KESSLER, S
通讯作者：
KESSLER, S
影响因子：
9.2
作者：
Chiang, Ann-Shyn;Lin, Chih-Yung;Hwang, Jenn-Kang
通讯作者：
Hwang, Jenn-Kang
影响因子：
4.5
作者：
Aso Y;Herb A;Ogueta M;Siwanowicz I;Templier T;Friedrich AB;Ito K;Scholz H;Tanimoto H
通讯作者：
Tanimoto H
影响因子：
11
作者：
Ben Zion, I. Z.;Tessler, R.;Ebstein, R. P.
通讯作者：
Ebstein, R. P.
影响因子：
48
作者：
Inagaki, Hidehiko K.;Jung, Yonil;Hoopfer, Eric D.;Wong, Allan M.;Mishra, Neeli;Lin, John Y.;Tsien, Roger Y.;Anderson, David J.
通讯作者：
Anderson, David J.