Ubiquitination in T-Cell Activation and Checkpoint Inhibition: New Avenues for Targeted Cancer Immunotherapy.
Ubiquitination in T-Cell Activation and Checkpoint Inhibition: New Avenues for Targeted Cancer Immunotherapy.
复制标题
T细胞活化和检查点抑制中的泛素化：靶向癌症免疫治疗的新途径。
DOI：
10.3390/ijms221910800
复制
发表时间：
2021-10-06
影响因子：
5.6
通讯作者：
Paolino M
中科院分区：
文献类型：
--
作者：
Gavali S;Liu J;Li X;Paolino M
基于T细胞的免疫疗法的出现显著改变了癌症患者的治疗。尽管他们的成功，目前批准的免疫方案仍然遇到限制，导致毒性，并给不同的患者结果。因此，更深入地了解T细胞激活和抑制的分子机制是非常必要的，以合理地扩大目标和可能性，以改善免疫治疗。免疫信号传导途径下游的蛋白质泛素化对于微调几乎所有的免疫应答是必不可少的，特别是T细胞活化的正向和负向调节。大量研究表明，泛素依赖性通路的失调可以显著改变T细胞活化并增强抗肿瘤反应。因此，学术界和工业界的研究人员正在积极开发技术，以选择性地利用泛素相关酶用于癌症治疗。在这篇综述中，我们讨论了泛素化在关键T细胞活化和检查点抑制途径中的分子和功能作用，以强调靶向泛素化为推进基于T细胞的免疫疗法提供的巨大可能性。
The advent of T-cell-based immunotherapy has remarkably transformed cancer patient treatment. Despite their success, the currently approved immunotherapeutic protocols still encounter limitations, cause toxicity, and give disparate patient outcomes. Thus, a deeper understanding of the molecular mechanisms of T-cell activation and inhibition is much needed to rationally expand targets and possibilities to improve immunotherapies. Protein ubiquitination downstream of immune signaling pathways is essential to fine-tune virtually all immune responses, in particular, the positive and negative regulation of T-cell activation. Numerous studies have demonstrated that deregulation of ubiquitin-dependent pathways can significantly alter T-cell activation and enhance antitumor responses. Consequently, researchers in academia and industry are actively developing technologies to selectively exploit ubiquitin-related enzymes for cancer therapeutics. In this review, we discuss the molecular and functional roles of ubiquitination in key T-cell activation and checkpoint inhibitory pathways to highlight the vast possibilities that targeting ubiquitination offers for advancing T-cell-based immunotherapies.
登录
查看更多内容
影响因子：
4.3
作者：
Appleman, Leonard J.;Chernova, Irene;Boussiotis, Vassiliki A.
通讯作者：
Boussiotis, Vassiliki A.
影响因子：
30.5
作者：
Coornaert, Beatrice;Baens, Mathijs;Beyaert, Rudi
通讯作者：
Beyaert, Rudi
影响因子：
15.9
作者：
Chiang, Jeffrey Y.;Jang, Ihn Kyung;Gu, Hua
通讯作者：
Gu, Hua
影响因子：
5.6
作者：
Andrea AE;Chiron A;Bessoles S;Hacein-Bey-Abina S
通讯作者：
Hacein-Bey-Abina S
影响因子：
64.8
作者：
Burr ML;Sparbier CE;Chan YC;Williamson JC;Woods K;Beavis PA;Lam EYN;Henderson MA;Bell CC;Stolzenburg S;Gilan O;Bloor S;Noori T;Morgens DW;Bassik MC;Neeson PJ;Behren A;Darcy PK;Dawson SJ;Voskoboinik I;Trapani JA;Cebon J;Lehner PJ;Dawson MA
通讯作者：
Dawson MA