Influence of estradiol on the secretion of oxytocin and prostaglandin F2 alpha during luteolysis in the ewe.
Influence of estradiol on the secretion of oxytocin and prostaglandin F2 alpha during luteolysis in the ewe.
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雌二醇对母羊黄体溶解过程中催产素和前列腺素 F2 α 分泌的影响。
DOI：
10.1095/biolreprod45.3.395
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发表时间：
1991
影响因子：
3.6
通讯作者：
Hixon Je
中科院分区：
文献类型：
--
作者：
J. Zhang;Weston Pg;Hixon Je
20只混合品种的母羊以相等数量随机分配到2 x 2析因设计的四个组中的一个。这些因素是X射线照射破坏卵泡或假照射和含雌二醇或空（安慰剂）植入剂的管理。在该周期第8天进行辐照手术。从第10天至第17天，每隔1.5小时从颈静脉导管中采集血样。在卵泡破坏后，至第17天，在5只安慰剂处理母羊中的4只中未观察到黄体溶解。在假辐照安慰剂治疗组的5只母羊中的4只和接受雌二醇的所有母羊中观察到黄体溶解，无论卵泡是否被破坏。在X射线照射的安慰剂治疗组中观察到13，14-二氢-15-酮-前列腺素F2 α（PGFM）峰之间的最长间隔（p <0.07），而雌二醇给药降低了PGFM峰之间的间隔（p <0.01）。这些发现表明前列腺素F2 α（PGF 2 α）分泌的短脉冲间期与黄体溶解有关。脉冲间期缩短可能是雌二醇引起黄体溶解的作用，也可能是黄体溶解引起的继发性事件。雌二醇的管理减少（p <0.05）的黄体溶解过程中催产素分泌的事件数和事件之间的间隔增加（p <0.01）。（250字处删节）
Twenty ewes of mixed breeds were randomly assigned in equal numbers to one of four groups in a 2 x 2 factorial design. The factors were x-irradiation to destroy ovarian follicles or sham irradiation and the administration of estradiol-containing or empty (placebo) implants. Surgery for irradiation was performed on Day 8 of the cycle. Blood samples were withdrawn from jugular catheters at 1.5-h intervals from Day 10 to Day 17. Luteolysis was not observed by Day 17 in 4 of 5 placebo-treated ewes after destruction of ovarian follicles. Luteolysis was observed in 4 of 5 ewes of the sham-irradiated, placebo-treated group and in all ewes that received estradiol whether or not ovarian follicles had been destroyed. The longest (p less than 0.07) interval between peaks of 13,14-dihydro-15-keto-prostaglandin F2 alpha (PGFM) was observed in the x-irradiated, placebo-treated group, whereas the administration of estradiol reduced (p less than 0.01) the interval between PGFM peaks. These findings indicate that a short interpulse interval in the secretion of prostaglandin F2 alpha (PGF2 alpha) is associated with luteolysis. It is possible that the reduced interpulse interval was either an effect of estradiol that caused luteolysis or a secondary event resulting from luteolysis. The administration of estradiol decreased (p less than 0.05) the number of episodes of oxytocin secretion during luteolysis and increased (p less than 0.01) the interval between episodes.(ABSTRACT TRUNCATED AT 250 WORDS)
母羊黄体中雌二醇的胞质受体：整个动情周期的变化以及大和小类固醇生成细胞类型之间的分布。
影响因子：
3.6
作者：
Glass,JD;Fitz,TA;Niswender,GD
通讯作者：
Niswender,GD
大鼠子宫中磷脂酶 A2 活性：类固醇激素的调节。
DOI：
10.1016/s0090-6980(82)80002-6
发表时间：
1982
期刊：
Prostaglandins
影响因子：
--
作者：
Dey,SK;Hoversland,RC;Johnson,DC
通讯作者：
Johnson,DC
松弛素在怀孕大鼠中的生理作用。
影响因子：
4.8
作者：
Downing,SJ;Sherwood,OD
通讯作者：
Sherwood,OD