COMbined Exercise Trial (COMET) to improve cognition in older adults: Rationale and methods.
COMbined Exercise Trial (COMET) to improve cognition in older adults: Rationale and methods.
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联合运动试验（COMET），以改善老年人的认知：原理和方法。
DOI：
10.1016/j.cct.2022.106805
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发表时间：
2022-07
影响因子：
2.2
通讯作者：
Vidoni, Eric D.
中科院分区：
文献类型：
--
作者：
Szabo-Reed, Amanda;Clutton, Jonathan;White, Sydney;Van Sciver, Angela;White, Dreu;Morris, Jill;Martin, Laura;Lepping, Rebecca;Shaw, Ashley;Puchalt, Jaime Perales;Montgomery, Robert;Mahnken, Jonathan;Washburn, Richard;Burns, Jeffrey;Vidoni, Eric D.
大量证据表明，体育锻炼可以维持认知功能，并可能预防阿尔茨海默病。目前的公共卫生建议要求老年人每周至少进行150分钟的有氧运动（例如步行）和每周两次的阻力运动（例如举重），以促进身体健康。然而，关于这些锻炼方式如何独立或组合地支持大脑健康，还有很多未知之处。联合运动试验（COMET）旨在测试有氧和阻力训练的综合和独立效果，特别关注1）认知能力，2）局部脑容量，3）身体功能和4）血液因素的运动相关变化。为了探索这些问题，我们将招募280名年龄在65-80岁之间的认知正常的老年人参加为期52周的社区锻炼计划。参与者将被随机分为四组：1）灵活性/调节-对照组，2）仅150分钟的有氧运动，3）仅渐进式阻力训练，或4）有氧和渐进式阻力训练相结合。评估的结局包括在基线、6个月和12个月时评估的综合认知组合、血液生物标志物、脑磁共振成像、生理生物标志物、心肺健康、身体功能和心理社会问卷组合。COMET将提供严格的随机对照试验数据，以了解最常见的运动方式及其组合（即，标准公共卫生建议），关于大脑健康。
Substantial evidence suggests physical exercise may sustain cognitive function and perhaps prevent Alzheimer’s Disease. Current public health recommendations call for older adults to do at least 150 minutes a week of aerobic exercise (e.g. walking) and twice a week resistance exercise (e.g. weight lifting) for physical health. Yet, much remains unknown about how these exercise modalities support brain health independently or in combination. The COMbined Exercise Trial (COMET) is designed to test the combined and independent effects of aerobic and resistance training specifically focusing on exercise-related changes in 1) cognitive performance, 2) regional brain volume, 3) physical function, and 4) blood-based factors. To explore these questions, we will enroll 280 cognitively normal older adults, age 65–80 years, into a 52-week community-based exercise program. Participants will be randomized into one of four arms: 1) flexibility/toning- control 2) 150 minutes of aerobic exercise only, 3) progressive resistance training only, or 4) combined aerobic and progressive resistance training. Outcomes assessed include a comprehensive cognitive battery, blood biomarkers, brain magnetic resonance imaging, physiological biomarkers, cardiorespiratory fitness, physical function, and battery of psychosocial questionnaires is assessed at baseline, 6 and 12-months. COMET will provide rigorous randomized controlled trial data to understand the effects of the most common exercise modalities, and their combination (i.e., the standard public health recommendation), on brain health.
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影响因子：
4
作者：
DESMOND, DW;TATEMICHI, TK;HANZAWA, L
通讯作者：
HANZAWA, L
影响因子：
5
作者：
COHEN, S;KAMARCK, T;MERMELSTEIN, R
通讯作者：
MERMELSTEIN, R
影响因子：
--
作者：
Davidson, Lance E.;Hudson, Robert;Ross, Robert
通讯作者：
Ross, Robert
DOI：
10.1249/00005768-198205000-00012
发表时间：
1982-01-01
期刊：
MEDICINE AND SCIENCE IN SPORTS AND EXERCISE
影响因子：
--
作者：
BORG, GAV
通讯作者：
BORG, GAV
DOI：
10.1073/pnas.1015950108
发表时间：
2011-02-15
影响因子：
11.1
作者：
Erickson, Kirk I.;Voss, Michelle W.;Kramer, Arthur F.
通讯作者：
Kramer, Arthur F.