Serological cross-reactivity using a SARS-CoV-2 ELISA test in acute Zika virus infection, Colombia.
Serological cross-reactivity using a SARS-CoV-2 ELISA test in acute Zika virus infection, Colombia.
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哥伦比亚急性寨卡病毒感染中使用SARS-COV-2 ELISA测试的血清学交叉反应性。
DOI：
10.1016/j.ijid.2020.09.1451
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发表时间：
2020-12
期刊：
影响因子：
--
通讯作者：
Contreras V
中科院分区：
文献类型：
--
作者：
Faccini-Martínez ÁA;Rivero R;Garay E;García A;Mattar S;Botero Y;Galeano K;Miranda J;Martínez C;Guzmán C;Arrieta G;Contreras H;Kerguelen H;Moscote M;Brango E;Contreras V
我们通过使用商业SARS-CoV-2 ELISA检测从不同人群收集的样本中调查了血清反应性，包括2015年至2019年期间诊断为登革热，寨卡和基孔肯雅感染的患者，来自加勒比哥伦比亚地区的流行区。本研究共纳入了从6个不同人群中获得的127份血清样本：A组：确诊的SARS-CoV-2感染患者; B组：有疑似COVID-19症状的患者或与确诊患者有无症状接触者; C组：急性或近期登革热病毒感染患者; D组：急性寨卡病毒感染患者; E组：既往感染基孔肯雅病毒的患者; F组：接触斑点热群立克次体的个体。总体而言，A组、B组和D组分别在92%、75%和26%的样本中显示出对SARS-CoV-2的血清反应性;此外，C组、E组和F组显示出100%的血清阴性。我们发现，通过使用商业SARS-CoV-2 ELISA检测，急性寨卡病毒感染患者的血清学交叉反应性为26%。需要进一步研究来评估血清学交叉反应是否会在既往接触过寨卡病毒的非急性患者中随着时间的推移而维持，以及其在该虫媒病毒流行地区SARS-CoV-2血清调查中的影响。
We investigated seroreactivity by using a commercial SARS-CoV-2 ELISA test in samples collected from different groups of individuals, including patients diagnosed to have Dengue, Zika, and Chikungunya infection between 2015 and 2019, from an endemic area in the Caribbean Colombian region. A total of 127 sera samples obtained from six different groups of individuals were included in this study: Group A: patients with confirmed SARS-CoV-2 infection; Group B: patients with symptoms suggestive of COVID-19 or asymptomatic contacts with confirmed patients; Group C: patients with acute or recent dengue virus infection; Group D: patients with acute Zika virus infection; Group E: patients with previous Chikungunya virus infection; and Group F: individuals with exposure to spotted fever group rickettsiae. Overall, group A, group B, and group D showed seroreactivity to SARS-CoV-2 in 92%, 75%, and 26% of samples, respectively; furthermore, group C, group E, and group F showed 100% seronegativity. We found 26% of serological cross-reactivity in patients with acute Zika virus infection by using a commercial SARS-CoV-2 ELISA test. Further studies are needed to evaluate whether serological cross-reaction is maintained with time in nonacute patients with previous exposure to the Zika virus and its effect in SARS-CoV-2 serosurveys in endemic areas for this arbovirus.
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DOI：
10.1186/s12941-019-0328-7
发表时间：
2019-10-14
影响因子：
5.7
作者：
Arrieta, German;Mattar, Salim;Doria, Amanda
通讯作者：
Doria, Amanda
影响因子：
3.3
作者：
Nunthavichitra, Surat;Prapaso, Suttiporn;Piyaphanee, Watcharapong
通讯作者：
Piyaphanee, Watcharapong
影响因子：
8.4
作者：
Mora-Salamanca, Andres Felipe;Porras-Ramirez, Alexandra;Restrepo, Fernando Pio De la Hoz
通讯作者：
Restrepo, Fernando Pio De la Hoz
影响因子：
11.8
作者：
Lustig, Yaniv;Keler, Shlomit;Vivante, Asaf
通讯作者：
Vivante, Asaf