Attention Performance Correlated With White Matter Structural Brain Networks in Shift Work Disorder.
Attention Performance Correlated With White Matter Structural Brain Networks in Shift Work Disorder.
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DOI：
10.3389/fpsyt.2021.802830
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发表时间：
2021
影响因子：
4.7
通讯作者：
Jia H
中科院分区：
文献类型：
--
作者：
Ning Y;Fang M;Zhang Y;Feng S;Feng Z;Liu X;Li K;Jia H
神经影像学研究表明，轮班工作障碍（SWD）影响了特定脑区和网络的功能连接。然而，与注意力功能相关的白色物质（WM）网络结构连接性的拓扑破坏仍然知之甚少。在本研究中，我们招募了33名SWD患者和29名匹配的健康受试者。注意网络测试（ANT）被用来调查的警觉，定向和执行控制网络的效率。采用弥散张量成像（DTI）纤维束成像技术构建WM结构网络。应用图论分析方法检测结构网络拓扑性质的变化。我们的研究结果显示，低警觉效果和高执行效果的SWD患者。使用基于链接的分析，15改变连接矩阵（较低的纤维数），发现两组之间。同时，图论分析表明，与健康对照组相比，SWD患者的整体效率和特征路径长度下降。此外，执行效果与全球网络效率之间存在显著的负相关。我们的研究结果提供了新的见解的基本架构的区域间结构连接的注意缺陷，这可能是一个潜在的生物标志物，SWD。
Neuroimaging studies have revealed that shift work disorder (SWD) affected the functional connectivity in specific brain regions and networks. However, topological disruptions in the structural connectivity of the white matter (WM) networks associated with attention function remain poorly understood. In the current study, we recruited 33 patients with SWD and 29 matched healthy subjects. The attention network test (ANT) was employed to investigate the efficiency of alerting, orienting, and executive control networks. The diffusion tensor imaging (DTI) tractography was used to construct the WM structural networks. The graph theory analysis was applied to detect the alterations of topological properties of structural networks. Our results showed lower alerting effect and higher executive effect for patients with SWD. Using the link-based analysis, 15 altered connectivity matrices (lower fiber numbers) were found between the two groups. Meanwhile, the graph theoretical analysis showed that the global efficiency and characteristic path length within SWD patients declined in contrast with the healthy controls. Furthermore, a significantly negative correlation was found between the executive effect and global network efficiency. Our findings provide the new insights into the fundamental architecture of interregional structural connectivity underlying attention deficits in SWD, which may be a potential biomarker for SWD.
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