The level of circulating endothelial progenitor cells may be associated with the occurrence and recurrence of chronic subdural hematoma.
The level of circulating endothelial progenitor cells may be associated with the occurrence and recurrence of chronic subdural hematoma.
复制标题
循环内皮祖细胞水平可能与慢性硬膜下血肿的发生和复发有关
DOI：
10.6061/clinics/2013(08)04
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发表时间：
2013
期刊：
影响因子：
--
通讯作者：
Zhang J
中科院分区：
文献类型：
--
作者：
Song Y;Wang Z;Liu L;Wang D;Zhang J
慢性硬膜下血肿的发生可能与头部的直接或间接轻微损伤或修复不良的血管损伤有关。内皮祖细胞是参与止血和血管修复的关键因素之一。本研究旨在观察慢性硬膜下血肿患者外周血中内皮祖细胞、白色细胞、血小板等指标的水平，以确定内皮祖细胞与慢性硬膜下血肿的发生、发展和转归之间的可能关系。我们纳入了2009年7月至2011年7月在天津医科大学总医院接受计算机断层扫描和手术治疗的30例慢性硬膜下血肿患者。同时采集30例50岁以上健康志愿者的外周血标本。手肘静脉采血约2ml，检测外周血常规及凝血功能。采用流式细胞仪测定外周血单个核细胞中内皮祖细胞的含量。术前慢性硬膜下血肿患者外周血内皮祖细胞水平明显低于对照组。两组患者的血常规、凝血功能比较差异无统计学意义。但复发组与非复发组循环内皮祖细胞水平差异有统计学意义。慢性硬膜下血肿患者循环内皮祖细胞水平明显低于健康对照组。复发患者的内皮祖细胞水平明显低于未复发患者。内皮祖细胞可能与慢性硬膜下血肿的发生和复发有关。
The onset of chronic subdural hematoma may be associated with direct or indirect minor injuries to the head or a poorly repaired vascular injury. Endothelial progenitor cells happen to be one of the key factors involved in hemostasis and vascular repair. This study was designed to observe the levels of endothelial progenitor cells, white blood cells, platelets, and other indicators in the peripheral blood of patients diagnosed with chronic subdural hematoma to determine the possible relationship between the endothelial progenitor cells and the occurrence, development, and outcomes of chronic subdural hematoma. We enrolled 30 patients with diagnosed chronic subdural hematoma by computer tomography scanning and operating procedure at Tianjin Medical University General Hospital from July 2009 to July 2011. Meanwhile, we collected 30 cases of peripheral blood samples from healthy volunteers over the age of 50. Approximately 2 ml of blood was taken from veins of the elbow to test the peripheral blood routine and coagulation function. The content of endothelial progenitor cells in peripheral blood mononuclear cells was determined by flow cytometry. The level of endothelial progenitor cells in peripheral blood was significantly lower in preoperational patients with chronic subdural hematomas than in controls. There were no significant differences between the two groups regarding the blood routine and coagulation function. However, the levels of circulating endothelial progenitor cells were significantly different between the recurrent group and the non-recurrent group. The level of circulating endothelial progenitor cells in chronic subdural hematoma patients was significantly lower than the level in healthy controls. Meanwhile, the level of endothelial progenitor cells in recurrent patients was significantly lower than the level in patients without recurrence. Endothelial progenitor cells may be related to the occurrence and recurrence of chronic subdural hematoma.
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影响因子：
56.9
作者：
Asahara, T;Murohara, T;Isner, JM
通讯作者：
Isner, JM
影响因子：
3.5
作者：
König, SA;Schick, U;Vitzthum, HE
通讯作者：
Vitzthum, HE
影响因子：
--
作者：
Hong, Hyun-Jong;Kim, Young-Jin;Kim, Jac-Min
通讯作者：
Kim, Jac-Min
影响因子：
24
作者：
Scheubel, RJ;Zorn, H;Simm, A
通讯作者：
Simm, A
影响因子：
6.2
作者：
Martin-Yuste, Victoria;Brugaletta, Salvatore;Sabate, Manel
通讯作者：
Sabate, Manel