Quetiapine treatment of zolpidem dependence.
Quetiapine treatment of zolpidem dependence.
复制标题
喹硫平治疗唑吡坦依赖性。
DOI：
10.1080/10550490701525467
复制
发表时间：
2007
期刊：
影响因子：
--
通讯作者：
Levin,FrancesR
中科院分区：
文献类型：
--
作者：
Mariani,JohnJ;Levin,FrancesR
我们报告 A 先生的病例，他是一名 52 岁的男性，终生有药物滥用史，对唑吡坦产生了依赖，并用喹硫平成功治疗。唑吡坦是一种短效非苯二氮卓催眠药，通过与 1 型苯二氮卓受体结合来增强 γ-氨基丁酸的作用。唑吡坦被认为具有较低的滥用潜力，1 但在高于推荐剂量时，其行为药理学与苯二氮卓类药物相似，2、3 和数十个唑吡坦滥用病例报告已被报道。 4先生。 A 有酒精、大麻和可卡因依赖史，但五年多以来否认使用任何酒精、大麻或可卡因。为了治疗失眠，A先生从内科医生那里得到了唑吡坦每天10毫克的处方。在六个月的时间里，他的用量逐渐增加到每天至少 40 毫克，但多次服用多达 250 毫克。他从网上药店购买了唑吡坦。使用大剂量唑吡坦会导致中毒和失忆。 A 先生住进戒毒所住院治疗，并用氯硝西泮治疗戒断症状，为期五天。出院后，患者出现严重失眠并渴望服用唑吡坦。曲唑酮剂量高达 200 mg QHS 的试验最初是有效的，但患者很快就对镇静作用产生了耐受性。加巴喷丁的试验遵循相同的模式：最初的疗效和对镇静作用的耐受性的快速发展。喹硫平治疗从 50 mg QHS 开始，并滴定至更高剂量，如下所示：
We report the case of Mr. A, a 52-year-old man with a lifelong history of substance use disorders who developed a dependence on zolpidem, which was successfully treated with quetiapine. Zolpidem is a short-acting nonbenzodiazepine hypnotic that potentiates gamma-aminobutyric acid by binding to benzodiazepine type 1 receptors. Zolpidem is thought to have low abuse potential, 1 but at higher than recommended doses, its behavioral pharmacology resembles that of benzodiazepines, 2, 3 and several dozen case reports of zolpidem abuse have been reported. 4Mr. A had a history of alcohol, cannabis, and cocaine dependence, but had denied using any alcohol, marijuana, or cocaine for more than five years. As a treatment for insomnia, Mr. A received a prescription for zolpidem 10 mg per day from his internist. Over a six-month period, his use escalated to a minimum of 40 mg per day, but on multiple episodes took as much as 250 mg. He purchased zolpidem from Internet-based pharmacies. High-dose zolpidem use resulted in intoxication and amnesia. Mr. A was admitted to an inpatient detoxification unit, and withdrawal symptoms were treated with clonazepam over a five-day period. After discharge, patient experienced severe insomnia and craving for zolpidem. A trial of trazodone in doses of up to 200 mg QHS was initially effective, but the patient rapidly developed a tolerance to the sedating effects. A trial of gabapentin followed the same pattern: initial efficacy and a rapid development of tolerance to the sedating effects. Quetiapine treatment was initiated at 50 mg QHS and titrated to higher doses as
登录
查看更多内容
真黑素自由基：量子产率和波长依赖性。
影响因子：
3.9
作者：
Sarna,T;Sealy,RC
通讯作者：
Sealy,RC
黑色素体（黑色素颗粒）中黑色化与酪氨酸酶活性之间的相互关系。
影响因子：
2.7
作者：
M. Seiji;Thomas B. Fitzpatrick
通讯作者：
Thomas B. Fitzpatrick
DOI：
10.1016/0006-291x(78)90175-4
发表时间：
1978-01-01
影响因子：
3.1
作者：
FELIX, CC;HYDE, JS;SEALY, RC
通讯作者：
SEALY, RC
黑色素与氧的相互作用。
影响因子：
3.9
作者：
T. Sarna;A. Duleba;W. Korytowski;H. Swartz
通讯作者：
H. Swartz