The role of altered lipid composition and distribution in liver fibrosis revealed by multimodal nonlinear optical microscopy.
The role of altered lipid composition and distribution in liver fibrosis revealed by multimodal nonlinear optical microscopy.
复制标题
多模态非线性光学显微镜揭示脂质成分和分布改变在肝纤维化中的作用
DOI：
10.1126/sciadv.abq2937
复制
发表时间：
2023-01-13
期刊：
影响因子：
13.6
通讯作者：
中科院分区：
文献类型：
--
作者：
Intracellular lipid accumulation is commonly seen in fibrotic livers, but its exact role in liver fibrosis remains elusive. Here, we established a multimodal nonlinear optical microscopy to quantitatively map distribution of biomolecules in fibrotic livers. Our data revealed that unsaturated triglycerides were predominantly accumulated in central vein area during liver fibrosis but not in portal vein area. Moreover, the lipid homeostasis was remarkably dysregulated in the late-stage compared to the early-stage fibrosis, including increased unsaturated triglycerides with decreased lipid unsaturation degree and decreased membrane fluidity. Such alterations were likely due to up-regulated lipogenesis, desaturation, and peroxidation, which consequently led to endoplasmic reticulum stress and cell death. Inspiringly, injured hepatocyte could be rescued by remodeling lipid homeostasis via either supply of unsaturated fatty acids or enhancement of membrane fluidity. Collectively, our study improves current understanding of the role of lipid homeostasis in fibrosis and open opportunities for treatment.
登录
查看更多内容
影响因子：
16.6
作者：
Lee SM;Lee SH;Jung Y;Lee Y;Yoon JH;Choi JY;Hwang CY;Son YH;Park SS;Hwang GS;Lee KP;Kwon KS
通讯作者：
Kwon KS
DOI：
10.1038/nrgastro.2017.32
发表时间：
2017-06
期刊：
Nature reviews. Gastroenterology & hepatology
影响因子：
--
作者：
Gluchowski NL;Becuwe M;Walther TC;Farese RV Jr
通讯作者：
Farese RV Jr
影响因子：
13.5
作者：
Liu, Feng;Goh, George Boon-Bee;Wei, Lai
通讯作者：
Wei, Lai
影响因子：
16.6
作者：
Du J;Su Y;Qian C;Yuan D;Miao K;Lee D;Ng AHC;Wijker RS;Ribas A;Levine RD;Heath JR;Wei L
通讯作者：
Wei L
影响因子：
4.6
作者：
Hall A;Cotoi C;Luong TV;Watkins J;Bhathal P;Quaglia A
通讯作者：
Quaglia A