Vinculin, an adapter protein in control of cell adhesion signalling.

Vinculin, an adapter protein in control of cell adhesion signalling.
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DOI:
10.1016/j.ejcb.2010.06.007
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发表时间:
2011-02
影响因子:
6.6
通讯作者:
Ballestrem, Christoph
Ballestrem, Christoph
中科院分区:
生物学3区
文献类型:
--
作者:
Carisey, Alex;Ballestrem, Christoph

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Vinculin发现于1979年,是一种具有超过15种蛋白质结合位点的适配蛋白。生化和结构分析有助于详细了解潜在的结合伙伴,并了解它们的结合是如何调节的。尽管有这么多的信息,但关于血管蛋白如何在细胞中起作用并控制各种信号的分子基础仍然难以捉摸。这篇综述的目的是强调最近的发现,重点是vinculin如何参与信号网络的协调。
Vinculin, discovered in 1979, is an adapter protein with binding sites for more than 15 proteins. Biochemical and structural analyses have contributed to detailed knowledge about potential binding partners and the understanding of how their binding may be regulated. Despite all this information the molecular basis of how vinculin acts in cells and controls a wide variety of signals remains elusive. This review aims to highlight recent discoveries with an emphasis on how vinculin is involved in the coordination of a network of signals.
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