Paracingulate Sulcus Morphology and Hallucinations in Clinical and Nonclinical Groups.
Paracingulate Sulcus Morphology and Hallucinations in Clinical and Nonclinical Groups.
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DOI：
10.1093/schbul/sby157
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发表时间：
2019-06-18
影响因子：
6.6
通讯作者：
Sommer IEC
中科院分区：
文献类型：
--
作者：
Garrison JR;Fernyhough C;McCarthy-Jones S;Simons JS;Sommer IEC
幻觉是精神病精神健康状况的一种特征症状，许多人在没有临床诊断的情况下也会经历这种症状。精神分裂症患者的幻觉与副齿状沟(PCS)长度的差异有关，PCS是内侧前额叶皮质的一种结构，此前一直与区分感知和想象信息的能力有关。我们通过检查有幻觉的非临床个体是否比没有幻觉的非临床个体有更短的PCS来调查幻觉的这一假定的形态学基础是否延伸到没有临床诊断的个体。检查了3组人口统计学匹配的个体的结构MRI扫描：50名患有幻听言语幻觉(AVH)的精神病患者，50名患有AVH的非临床个体，以及50名没有一生幻觉史的健康对照受试者。使用自动数据驱动回转分析验证了结果。有幻觉的患者的PCS比健康对照组和有幻觉的非临床个体都要短，而非临床的有幻觉的个体和健康对照组之间没有差异。这些发现表明，较短的PCS长度与幻觉的联系是精神障碍患者特有的。这对精神病的全连续模型提出了挑战，并暗示了临床组和非临床组产生幻觉的机制可能存在的差异。
Hallucinations are a characteristic symptom of psychotic mental health conditions that are also experienced by many individuals without a clinical diagnosis. Hallucinations in schizophrenia have been linked to differences in the length of the paracingulate sulcus (PCS), a structure in the medial prefrontal cortex which has previously been associated with the ability to differentiate perceived and imagined information. We investigated whether this putative morphological basis for hallucinations extends to individuals without a clinical diagnosis, by examining whether nonclinical individuals with hallucinations have shorter PCS than nonclinical individuals without hallucinations. Structural MRI scans were examined from 3 demographically matched groups of individuals: 50 patients with psychotic diagnoses who experienced auditory verbal hallucinations (AVHs), 50 nonclinical individuals with AVHs, and 50 healthy control subjects with no life-time history of hallucinations. Results were verified using automated data-driven gyrification analyses. Patients with hallucinations had shorter PCS than both healthy controls and nonclinical individuals with hallucinations, with no difference between nonclinical individuals with hallucinations and healthy controls. These findings suggest that the association of shorter PCS length with hallucinations is specific to patients with a psychotic disorder. This presents challenges for full-continuum models of psychosis and suggests possible differences in the mechanisms underlying hallucinations in clinical and nonclinical groups.
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影响因子：
4.5
作者：
Allen, Paul;Freeman, Daniel;McGuire, Philip
通讯作者：
McGuire, Philip
影响因子：
6.6
作者：
Johns LC;Kompus K;Connell M;Humpston C;Lincoln TM;Longden E;Preti A;Alderson-Day B;Badcock JC;Cella M;Fernyhough C;McCarthy-Jones S;Peters E;Raballo A;Scott J;Siddi S;Sommer IE;Larøi F
通讯作者：
Larøi F
影响因子：
16.6
作者：
Garrison JR;Fernyhough C;McCarthy-Jones S;Haggard M;Australian Schizophrenia Research Bank;Simons JS
通讯作者：
Simons JS
影响因子：
10.5
作者：
CLARIDGE, G
通讯作者：
CLARIDGE, G
影响因子：
10.5
作者：
Johns, LC;Cannon, M;Meltzer, H
通讯作者：
Meltzer, H