Influence of membrane properties on spike synchronization in neurons: theory and experiments
Influence of membrane properties on spike synchronization in neurons: theory and experiments
复制标题
膜特性对神经元尖峰同步的影响：理论与实验
DOI：
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发表时间：
2003
期刊：
影响因子：
--
通讯作者：
J. Hounsgaard
中科院分区：
文献类型：
--
作者：
G. Svirskis;J. Hounsgaard
在大脑中，神经元的尖峰同步参与信息传递和某些形式的功能障碍。随机点过程理论用于将输入点过程的统计特性与被视为阈值设备的神经元放电之间的同步联系起来。导出的分析关系描述了具有平衡激励和抑制的共享输入情况下的归一化同步。对于具有不平衡共享输入和尖峰生成霍奇金-赫胥黎型电导的神经元模型，该理论令人满意地描述了尖峰同步对尖峰之间延迟的时间依赖性。使用计算机生成的随机刺激电流来刺激海龟脊髓切片中的运动神经元。当在计算中使用膜时间常数和测量的相对尖峰阈值时，理论能够近似尖峰同步对尖峰之间的延迟的时间依赖性。与理论预测一致，当通过注入稳定的去极化偏置电流降低尖峰生成阈值时，归一化尖峰同步性降低。在脊髓运动神经元中，某些代谢递质受体激活所促进的持续内向电流可以降低相对尖峰阈值。感应该内向电流尖峰后，同步性降低了数倍。有人认为，通过破坏脑干调节系统（如帕金森病）来下调运动神经元的持续内向电流，可以由于运动神经元之间的同步性增加而促进震颤。
In the brain spike synchronization in neurons is involved in information transfer and certain forms of dysfunction. The theory of random point processes was used to relate the statistical properties of input point processes to synchronization between firing in neurons viewed as threshold devices. Derived analytical relations describe normalized synchronization in the case of shared input with balanced excitation and inhibition. For neuronal models with unbalanced shared input and spike generating Hodgkin–Huxley type conductances, the theory satisfactorily describes the temporal dependence of spike synchronization on the delay between spikes. Computer generated stochastic stimulus current was used to stimulate motoneurons in turtle spinal cord slices. Theory was able to approximate the temporal dependence of spike synchronization on the delay between spikes when the membrane time constant and the relative spike threshold measured were used in calculations. In agreement with the theoretical prediction, normalized spike synchrony was reduced when the threshold for spike generation was lowered by injection of steady depolarizing bias current. In spinal motoneurons the relative spike threshold can be lowered by a persistent inward current facilitated by activation of certain metabotropic transmitter receptors. After induction of this inward current spike synchronization was reduced several times. It is suggested that downregulation of the persistent inward current in motoneurons by disruption of brainstem modulatory systems, as in Parkinson disease, can facilitate tremor due to the increased synchrony between motoneurons.
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常见兴奋性和抑制性输入对运动神经元同步的影响。
DOI：
10.1152/jn.2001.86.6.2807
发表时间：
2001
期刊：
Journal of neurophysiology.
影响因子：
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作者：
Turker,KS;Powers,RK
通讯作者：
Powers,RK
DOI：
--
发表时间：
1998
期刊：
The Journal of physiology
影响因子：
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作者：
N. Hardingham;A. Larkman
通讯作者：
N. Hardingham;A. Larkman
影响因子：
56.9
作者：
Anderson, JS;Lampl, I;Ferster, D
通讯作者：
Ferster, D
突触对运动神经元放电率影响的放大和线性求和。
DOI：
10.1152/jn.2001.85.1.43
发表时间：
2001
期刊：
Journal of neurophysiology.
影响因子：
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作者：
Prather,JF;Powers,RK;Cope,TC
通讯作者：
Cope,TC