Integration of Synaptic and Intrinsic Conductances Shapes Microcircuits in the Superior Olivary Complex
Integration of Synaptic and Intrinsic Conductances Shapes Microcircuits in the Superior Olivary Complex
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突触和内在电导的整合塑造了上橄榄复合体中的微电路
DOI：
10.1007/978-3-319-71798-2_5
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发表时间：
2018
期刊：
影响因子：
--
通讯作者：
Forsythe ID
中科院分区：
文献类型：
--
作者：
Kopp-Scheinpflug C;Forsythe ID
上橄榄核复合体是一组相互连接的脑干核，接收和整合双耳听觉输入。每个核构成局部微电路的一部分，在听觉处理中起着多种互补作用，包括声音定位、噪声信号检测和间隙检测。梯形体的三个核（内侧、外侧和腹侧）提供间接的局部抑制性投射，这些投射与三个输出核（内侧和外侧上橄榄核和上橄榄旁核）上耳蜗核的直接兴奋输入相结合。每个细胞核表达不同的离子电导谱，这决定了其主要神经元的内在兴奋性，并适应微电路如何整合双耳兴奋性和抑制性突触输入。特殊的突触，如Held的花萼，有助于维持时间信息和减少抖动，而突触在特定树突或体细胞区域的位置提供了微电路的进一步完善。本章还包括每个核的主神经元如何表达不同密度的离子电导，从而表现出独特的阈值、动作电位波形和特征放电特性。将提供一个广阔的视角，这些功能元素如何聚集在一起，塑造局部神经元微电路，以执行特定的生理作用，以进行耳间时间识别，耳间水平识别和间隙检测。
The superior olivary complex is a group of interconnected brainstem nuclei that receive and integrate binaural auditory input. Each nucleus forms part of local microcircuits subserving multiple complimentary roles in auditory processing, including sound localization, detection of signals in noise, and gap detection. The three nuclei of the trapezoid body (medial, lateral, and ventral) provide indirect inhibitory local projections that are integrated with direct excitatory inputs from the cochlear nuclei at the three output nuclei (the medial and lateral superior olivary nuclei and the superior paraolivary nucleus). Each nucleus expresses a different spectrum of ionic conductances that determine the intrinsic excitability of their principal neurons and adapt how the microcircuit integrates the binaural excitatory and inhibitory synaptic inputs. Specialized synapses, such as the calyx of Held, help maintain temporal information and minimize jitter, while the location of synapses on specific dendrites or somatic regions provides further refinement of the microcircuit. This chapter also includes how the principal neurons of each nucleus express differing densities of ionic conductance by which they exhibit a unique threshold, action potential waveform, and characteristic firing properties. A broad perspective will be provided on how each of these functional elements come together to sculpt the local neuronal microcircuit into performing specific physiological roles for interaural timing discrimination, interaural level discrimination, and gap detection.
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声音诱发的活动会影响梯形体内脑干轴突的髓鞘形成。
DOI：
10.1523/jneurosci.3728-16.2017
发表时间：
2017-08-23
期刊：
The Journal of neuroscience : the official journal of the Society for Neuroscience
影响因子：
--
作者：
Sinclair JL;Fischl MJ;Alexandrova O;Heβ M;Grothe B;Leibold C;Kopp-Scheinpflug C
通讯作者：
Kopp-Scheinpflug C
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影响因子：
3.4
作者：
R. Leão;Katarina Svahn;A. Berntson;B. Walmsley
通讯作者：
B. Walmsley
花萼型突触突触传递过程中三种不同途径介导的突触后 Ca2 流入
DOI：
10.1523/jneurosci.18-24-10409.1998
发表时间：
1998
期刊：
The Journal of Neuroscience
影响因子：
--
作者：
Johann H. Bollmann;F. Helmchen;J. Borst;B. Sakmann
通讯作者：
B. Sakmann
甘氨酸介导的哺乳动物中央突触起始可靠性的变化
影响因子：
3.3
作者：
C. Kopp‐Scheinpflug;Susanne Dehmel;Sandra Tolnai;Beatrice Dietz;I. Milenkovic;R. Rübsamen
通讯作者：
R. Rübsamen
影响因子：
5.5
作者：
FORSYTHE, ID
通讯作者：
FORSYTHE, ID