Boolean versus continuous dynamics in modules with two feedback loops
Boolean versus continuous dynamics in modules with two feedback loops
复制标题
具有两个反馈回路的模块中的布尔动态与连续动态
DOI:
10.1140/epje/i2012-12107-9
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发表时间:
2012
期刊:
影响因子:
--
通讯作者:
Barbara
中科院分区:
文献类型:
--
作者:
Ackermann;Eva Marie ;Torsten ;Drossel;Barbara
We investigate the dynamical behavior of simple networks, namely loops with an additional internal regulating connection. Continuous dynamics for mRNA and protein concentrations is compared to a Boolean model for gene activity. Using a generalized method and within a single framework, we study different continuous models and different types of regulatory functions, and establish conditions under which the system can display stable oscillations or stable fixed points. These conditions depend only on general features such as the degree of cooperativity of the regulating interactions and the logical structure of the interactions. There are no simple rules for deciding when Boolean and continuous dynamics agree with each other, but we identify several relevant criteria.
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影响因子:
2.4
作者:
Gross, T;Feudel, U
通讯作者:
Feudel, U
DOI:
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发表时间:
2004
期刊:
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作者:
Thilo Gross
通讯作者:
Thilo Gross
DOI:
10.1103/physreve.76.046122
发表时间:
2007
期刊:
Physical review. E, Statistical, nonlinear, and soft matter physics
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作者:
J. Norrell;B. Samuelsson;J. Socolar
通讯作者:
J. Socolar
DOI:
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发表时间:
2009
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作者:
M. Jensen;S. Pigolotti;Sandeep Krishna
通讯作者:
Sandeep Krishna
DOI:
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发表时间:
2009
期刊:
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