Toward better drug repositioning: prioritizing and integrating existing methods into efficient pipelines.
Toward better drug repositioning: prioritizing and integrating existing methods into efficient pipelines.
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DOI：
10.1016/j.drudis.2013.11.005
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发表时间：
2014-05
影响因子：
7.4
通讯作者：
Wong, Stephen T. C.
中科院分区：
文献类型：
--
作者：
Jin, Guangxu;Wong, Stephen T. C.
回收旧药、挽救搁置的药物和延长专利的寿命使药物重新定位成为一种有吸引力的药物发现形式。在美国食品和药物管理局（FDA）近年来新批准的药物和疫苗中，药物重新定位约占30%。药物重新定位研究的流行导致了各种创新的计算方法，用于识别使用旧药物的新机会。问题往往出现在定制或优化这些方法到有效的药物重新定位管道的替代应用。它需要通过评估生物学和药学知识以及阐明的药物作用机制来全面了解可用的方法。在这里，我们为特定药物重新定位管道的药物重新定位方法的优先级和整合提供指导。
Recycling old drugs, rescuing shelved drugs and extending patents' lives make drug repositioning an attractive form of drug discovery. Drug repositioning accounts for approximately 30% of the newly US Food and Drug Administration (FDA)-approved drugs and vaccines in recent years. The prevalence of drug-repositioning studies has resulted in a variety of innovative computational methods for the identification of new opportunities for the use of old drugs. Questions often arise from customizing or optimizing these methods into efficient drug-repositioning pipelines for alternative applications. It requires a comprehensive understanding of the available methods gained by evaluating both biological and pharmaceutical knowledge and the elucidated mechanism-of-action of drugs. Here, we provide guidance for prioritizing and integrating drug-repositioning methods for specific drug-repositioning pipelines.
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影响因子：
5.6
作者：
Crisman, Thomas J.;Parker, Christian N.;Glick, Meir
通讯作者：
Glick, Meir
影响因子：
14.9
作者：
Chatr-Aryamontri A;Breitkreutz BJ;Heinicke S;Boucher L;Winter A;Stark C;Nixon J;Ramage L;Kolas N;O'Donnell L;Reguly T;Breitkreutz A;Sellam A;Chen D;Chang C;Rust J;Livstone M;Oughtred R;Dolinski K;Tyers M
通讯作者：
Tyers M
DOI：
10.1007/s12094-006-0048-2
发表时间：
2006-07-01
期刊：
Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico
影响因子：
--
作者：
Carnero, A
通讯作者：
Carnero, A
影响因子：
56.9
作者：
Campillos, Monica;Kuhn, Michael;Bork, Peer
通讯作者：
Bork, Peer
影响因子：
3
作者：
Bisgin H;Liu Z;Kelly R;Fang H;Xu X;Tong W
通讯作者：
Tong W