Dose-Response Meta-Analysis on Tooth Loss With the Risk of Cognitive Impairment and Dementia.
Dose-Response Meta-Analysis on Tooth Loss With the Risk of Cognitive Impairment and Dementia.
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DOI：
10.1016/j.jamda.2021.05.009
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发表时间：
2021-10
影响因子：
7.6
通讯作者：
Wu B
中科院分区：
文献类型：
--
作者：
Qi X;Zhu Z;Plassman BL;Wu B
量化牙齿脱落与认知障碍和痴呆风险之间的剂量反应关系。研究人员对截至2020年3月1日的6个数据库进行了系统性检索，以研究牙齿脱落与认知功能之间的关系。本研究遵循系统性综述和荟萃分析（PRISMA）报告指南的首选报告项目。使用随机效应模型汇总风险估计值。使用广义最小二乘样条模型评估剂量-反应相关性。来自社区、机构、门诊或住院的成年人被纳入荟萃分析。认知障碍和痴呆症的定义是神经心理学测试，诊断标准，或医疗记录。牙齿脱落是自我报告或通过临床检查评估的。14项研究进入荟萃分析，包括34，074名参与者和4，689例认知功能减退的病例。牙齿脱落较多的参与者发生认知障碍的风险高1.48倍（95%CI = 1.18-1.87），被诊断为痴呆的风险高1.28倍（95%CI = 1.09-1.49）。然而，对于使用义齿的参与者，这种关联不显著（RR = 1.10，95%CI = 0.90-1.11）。8项研究纳入剂量-反应分析，数据支持使用线性模型。每多掉一颗牙，认知障碍的相对风险增加0.014，痴呆的相对风险增加0.011。无牙参与者面临的认知障碍风险高1.54倍，被诊断为痴呆症的风险高1.40倍。中等质量的证据表明，牙齿脱落与认知障碍和痴呆独立相关;认知功能下降的风险随着牙齿脱落数量的增加而增加。此外，及时使用义齿进行修复治疗可能会减少与牙齿缺失相关的认知能力下降的进展。进行了一项荟萃分析，研究牙齿脱落与认知障碍和痴呆风险之间的剂量反应关系。我们发现，每多掉一颗牙，认知障碍的相对风险增加0.014，痴呆的相对风险增加0.011。
To quantify the dose-response associations between tooth loss and risk of cognitive impairment and dementia. Longitudinal studies that examined the association between tooth loss and cognitive function were systematically searched on six databases through March 1, 2020. The study adhered to Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) reporting guidelines. Risk estimates were pooled using random-effects models. The dose-response associations were assessed using generalized least squares spline models. Adults from community, institution, out-patient or in-hospital were included in the meta-analysis. Cognitive impairment and dementia were defined by neuropsychological tests, diagnostic criteria, or medical records. Tooth loss was self-reported or assessed by clinical examinations. Fourteen studies were entered into the meta-analysis, including 34,074 participants and 4,689 cases with diminished cognitive function. Participants with more tooth loss had a 1.48 times higher risk of developing cognitive impairment (95% CI = 1.18–1.87) and 1.28 times higher risk of being diagnosed with dementia (95% CI = 1.09–1.49). However, the association was non-significant for participants using dentures (RR = 1.10, 95% CI = 0.90–1.11). Eight studies were included in the dose-response analysis, and data supported the use of linear models. Each additional tooth loss was associated with a 0.014 increased relative risk of cognitive impairment and 0.011 elevated relative risks of dementia. Edentulous participants faced a 1.54 times higher risk of cognitive impairment and a 1.40 times higher risk of being diagnosed with dementia. Moderate-quality evidence suggested tooth loss was independently associated with cognitive impairment and dementia; risk of diminished cognitive function increased with incremental numbers of teeth lost. Furthermore, timely prosthodontic treatment with dentures may reduce the progression of cognitive decline related to tooth loss. A meta-analysis examining a dose-response association between tooth loss and risk of cognitive impairment and dementia was performed. We found each additional tooth lost was associated with a 0.014 increased relative risk of cognitive impairment and a 0.011 elevated relative risk of dementia.
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影响因子：
5
作者：
GREENLAND, S;LONGNECKER, MP
通讯作者：
LONGNECKER, MP
影响因子：
4.4
作者：
Cerutti-Kopplin, Daiane;Emami, Elham;Pereira Padilha, Dalva Maria
通讯作者：
Pereira Padilha, Dalva Maria
DOI：
10.1016/j.jamda.2011.01.014
发表时间：
2011-09-01
影响因子：
7.6
作者：
Boyd, Michal;Broad, Joanna B.;Connolly, Martin J.
通讯作者：
Connolly, Martin J.
影响因子：
--
作者：
Cerutti-Kopplin, D;Feine, J;Emami, E
通讯作者：
Emami, E
影响因子：
4.2
作者：
Dintica, Christina S.;Rizzuto, Debora;Xu, Weili
通讯作者：
Xu, Weili