Correlation of magnetization transfer ration with clinical disability in multiple sclerosis
Correlation of magnetization transfer ration with clinical disability in multiple sclerosis
复制标题
多发性硬化症磁化转移率与临床残疾的相关性
作者：
MD A. Gass;PhD G. J. Barker;Mrcp D. Kidd;Mrcp J. W. Thorpe;Dcr D. MacManus;Dcr A. Brennan;P. Tofts;A. J. DPhil;MD W. I Thompson;PhD D. H McDonald;MD Miller;G. Barker;J. Thorpe;P. Tofts;A. Thompson;Miller DH. Ann McDonald WI;Neurol
我们对43例多发性硬化（MS）患者、10例年龄匹配的对照组和4例影像学诊断为小血管疾病的老年无症状患者进行了自旋回波磁共振成像（有和无非共振饱和脉冲）。由此获得磁化传递（MT）定量图像。所有MS亚组（原发性进展性、继发性进展性、良性、早期复发缓解型）的平均病变MT比率均显著低于小血管疾病患者。继发性进展型MS患者的病变MT比率显著低于良性疾病患者，并且残疾与平均病变MT比率呈负相关。MT比率的降低程度是组织破坏程度的指标。因此，MS中MT比率的降低可以提供脱髓鞘和轴突损失程度的指示，这两者都可能导致MS的功能缺陷。我们得出结论，MT测量是（1）一种可靠的定量方法，可以增加磁共振成像的病理特异性，（2）有可能区分MS中的脱髓鞘和破坏性较小的病理变化，和（3）可用于监测治疗引起的组织结构的改变。
We performed spin echo magnetic resonance imaging with and without application of an off‐resonance saturation pulse in 43 patients with multiple selerosis (MS), 10 age‐matched controls, and 4 elderly asymptomatic patients with the radiological diagnosis of small‐vessel disease. Magnetization transfer (MT) ration images were obtained from these. All MS subgroups (primary progressive, secondary progressive, benign, early relapsing–remitting) showed significantly lower average lesion MT ratios than small‐vessel disease patients. Secondary progressive MS patients showed significantly lower lesion MT ratios than those with benign disease, and there was an inverse correlaion of disability with average lesion MT ratio. The degree of reduction of MT ratios is an indicator of the extent of tissue destruction. Thus, reduced MT ratios in MS may provide an indication of the degree of demyelination and axonal loss, both of which are likely to cause functional deficits in MS. We conclude that MT measurement is (1) a robust quantitative method that may increase the pathological specificity of magnetic resonance imaging, (2) has the potential to differentiate demyelination in MS from less destructive pathological changes, and (3) may be useful in monitoring modifications in tissue structure brought about by treatment.
影响因子：
19.7
作者：
DOUSSET, V;GROSSMAN, RI;COHEN, JA
通讯作者：
COHEN, JA