Staphylococcus aureus manganese transport protein C is a highly conserved cell surface protein that elicits protective immunity against S. aureus and Staphylococcus epidermidis.
Staphylococcus aureus manganese transport protein C is a highly conserved cell surface protein that elicits protective immunity against S. aureus and Staphylococcus epidermidis.
复制标题
DOI：
10.1093/infdis/jis272
复制
发表时间：
2012-06
期刊：
影响因子：
--
通讯作者：
Jansen KU
中科院分区：
文献类型：
--
作者：
Anderson AS;Scully IL;Timofeyeva Y;Murphy E;McNeil LK;Mininni T;Nuñez L;Carriere M;Singer C;Dilts DA;Jansen KU
金黄色葡萄球菌和其他葡萄球菌会引起严重的人类疾病，目前还没有可用的疫苗。我们评估了在葡萄球菌物种组中保守的锰转运蛋白 C (MntC) 是否可以提供针对金黄色葡萄球菌和表皮葡萄球菌的保护。金黄色葡萄球菌 MntC 表达的体内分析表明，表达发生在感染周期的早期。在急性鼠菌血症模型中，MntC 主动免疫可有效减少与金黄色葡萄球菌和表皮葡萄球菌感染相关的细菌负荷。已鉴定出抗 MntC 单克隆抗体可以结合金黄色葡萄球菌和表皮葡萄球菌细胞，在幼年大鼠被动保护模型中具有保护作用，并诱导中性粒细胞呼吸爆发活动。这是对有可能为葡萄球菌物种组提供保护的蛋白质的首次描述。
Staphylococcus aureus and other staphylococci cause severe human disease, and there are currently no vaccines available. We evaluated whether manganese transport protein C (MntC), which is conserved across the staphylococcal species group, could confer protection against S. aureus and Staphylococcus epidermidis. In vivo analysis of S. aureus MntC expression revealed that expression occurs very early during the infectious cycle. Active immunization with MntC was effective at reducing the bacterial load associated with S. aureus and S. epidermidis infection in an acute murine bacteremia model. Anti-MntC monoclonal antibodies have been identified that can bind S. aureus and S. epidermidis cells and are protective in an infant rat passive protection model and induce neutrophil respiratory burst activity. This is the first description of a protein that has the potential to provide protection across the staphylococcal species group.
登录
查看更多内容
影响因子：
3.6
作者：
Tseng, HJ;Srikhanta, Y;Jennings, MP
通讯作者：
Jennings, MP
影响因子：
2.6
作者：
Johne, B
通讯作者：
Johne, B
影响因子：
--
作者：
Raedler, Michael D.;Heyne, Samantha;Esser, Mark T.
通讯作者：
Esser, Mark T.
影响因子：
3.1
作者：
Sellman, BR;Howell, AP;Baker, SM
通讯作者：
Baker, SM
影响因子：
15.9
作者：
JOHNSTON, RB;KEELE, BB;RAJAGOPALAN, KV
通讯作者：
RAJAGOPALAN, KV