Calcium release-activated calcium channels and pain.
Calcium release-activated calcium channels and pain.
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DOI：
10.1016/j.ceca.2018.07.009
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发表时间：
2018-09
期刊：
影响因子：
4
通讯作者：
Hu H
中科院分区：
文献类型：
--
作者：
Mei Y;Barrett JE;Hu H
Calcium release-activated calcium (CRAC) channels are unique among ion channels that are activated in response to depletion of intracellular calcium stores and are highly permeable to Ca2+ compared to other cations. CRAC channels mediate an important calcium signal for a wide variety of cell types and are well studied in the immune system. They have been implicated in a number of disorders such as immunodeficiency, musculosketal disorders and cancer. There is growing evidence showing that CRAC channels are expressed in the nervous system and are involved in pathological conditions including pain. This review summarizes the expression, distribution, and function of the CRAC channel family in the dorsal root ganglion, spinal cord and some brain regions, and discusses their functional significance in neurons and glial cells and involvement in nociception and chronic pain. Although further studies are needed to understand how these channels are activated under physiological conditions, the recent findings indicate that the CRAC channel Orai1 is an important player in pain modulation and could represent a new target for pathological pain.
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影响因子：
4.6
作者：
Chen JJ;Dai L;Zhao LX;Zhu X;Cao S;Gao YJ
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Gao YJ
DOI：
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发表时间：
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期刊：
The Journal of neuroscience : the official journal of the Society for Neuroscience
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9.3
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5.3
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