Intrathecal curcumin attenuates pain hypersensitivity and decreases spinal neuroinflammation in rat model of monoarthritis.
Intrathecal curcumin attenuates pain hypersensitivity and decreases spinal neuroinflammation in rat model of monoarthritis.
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鞘内注射姜黄素可减轻单关节炎大鼠模型的疼痛过敏并减少脊髓神经炎症
DOI：
10.1038/srep10278
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发表时间：
2015-05-19
影响因子：
4.6
通讯作者：
Gao YJ
中科院分区：
文献类型：
--
作者：
Chen JJ;Dai L;Zhao LX;Zhu X;Cao S;Gao YJ
姜黄素是姜黄的主要成分，据报道具有抗炎和抗氧化作用。神经炎症在中枢神经系统多种疾病的发病机制中起重要作用。在这里，我们研究了姜黄素对大鼠关节炎疼痛的抗伤害性和抗神经炎症作用。我们发现，在完全弗氏佐剂（CFA）注射之前或之后，重复口服姜黄素治疗，剂量依赖性地减弱CFA诱导的机械异常性疼痛和热痛觉过敏，但对关节水肿没有影响。重复鞘内注射姜黄素逆转CFA诱导的疼痛超敏反应。此外，这种姜黄素治疗减少了脊髓中CFA诱导的胶质细胞活化和炎症介质[白细胞介素-1 β（IL-1β），单核细胞趋化蛋白-1（MCP-1）和单核细胞炎症蛋白-1（MIP-1α）]的产生。姜黄素还能降低脂多糖诱导的星形胶质细胞和小胶质细胞产生IL-1β、肿瘤坏死因子-α、MCP-1和MIP-1α。我们的研究结果表明，鞘内注射姜黄素通过抑制脊髓中神经胶质细胞活化和炎症介质的产生来减轻关节炎疼痛，这表明姜黄素用于治疗关节炎疼痛的新应用。
Curcumin is a major component of turmeric and reportedly has anti-inflammatory and anti-oxidant effects. Neuroinflammation has been recognized to play an important role in the pathogenesis of various diseases in the central nervous system. Here we investigated the anti-nociceptive and anti-neuroinflammatory effect of curcumin on arthritic pain in rats. We found that repeated oral treatment with curcumin, either before or after complete Freund’s adjuvant (CFA) injection, dose-dependently attenuated CFA-induced mechanical allodynia and thermal hyperalgesia, but had no effect on joint edema. Repeated intrathecal injection of curcumin reversed CFA-induced pain hypersensitivity. Furthermore, such a curcumin treatment reduced CFA-induced activation of glial cells and production of inflammatory mediators [interleukin-1β (IL-1β), monocyte chemoattractant protein-1 (MCP-1) and monocyte inflammatory protein-1 (MIP-1α)] in the spinal cord. Curcumin also decreased lipopolysaccharide-induced production of IL-1β, tumor necrosis factor-α, MCP-1 and MIP-1α in cultured astrocytes and microglia. Our results suggest that intrathecal curcumin attenuates arthritic pain by inhibiting glial activation and the production of inflammatory mediators in the spinal cord, suggesting a new application of curcumin for the treatment of arthritic pain.
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影响因子：
15.9
作者：
Ji RR;Xu ZZ;Strichartz G;Serhan CN
通讯作者：
Serhan CN
DOI：
10.3344/kjp.2012.25.1.1
发表时间：
2012-01
期刊：
The Korean journal of pain
影响因子：
--
作者：
Han YK;Lee SH;Jeong HJ;Kim MS;Yoon MH;Kim WM
通讯作者：
Kim WM
影响因子：
4.7
作者：
Gao YJ;Ji RR
通讯作者：
Ji RR
影响因子：
6.1
作者：
Maheshwari, RK;Singh, AK;Srimal, RC
通讯作者：
Srimal, RC
影响因子：
2.9
作者：
Al Moundhri, Mansour S.;Al-Salam, Suhail;Ali, Badreldin H.
通讯作者：
Ali, Badreldin H.