Sphingolipids in COPD.
Sphingolipids in COPD.
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DOI：
10.1183/16000617.0047-2019
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发表时间：
2019-12-31
影响因子：
7.5
通讯作者：
Epelbaum, Oleg
中科院分区：
文献类型：
--
作者：
Chakinala, Raja Chandra;Khatri, Akshay;Gupta, Kriti;Koike, Kengo;Epelbaum, Oleg
鞘脂是广泛存在于自然界中的一类独特的脂质分子，主要作为细胞膜成分。在最初对其功能的不确定性之后，鞘脂已越来越多地被认为是参与许多生物过程的代谢活性实体，包括炎症的控制。它们作为炎症介质的作用可能对一系列肺部疾病具有重要意义，其中炎症是发病机制的核心要素。慢性阻塞性肺疾病（COPD）是一种高度流行的疾病，主要影响吸烟者，是具有炎症成分的呼吸系统疾病的主要例子。可以理解的是，鞘脂在COPD的病理生理学中的作用越来越受到关注。本综述旨在成为第一个专门关注鞘脂与COPD肺部炎症之间联系的文献，为读者提供这一有趣联系的临床导向概要。据推测，鞘脂在COPD的发病机制中发挥作用。对COPD中鞘脂病理生物学的理解取得了进展，已确定了推定的治疗靶点。http://bit.ly/2KVwbj4
Sphingolipids are a distinct class of lipid molecules widely found in nature, principally as cell membrane constituents. After initial uncertainty about their function, sphingolipids have been increasingly recognised to be metabolically active entities involved in many biological processes, including the control of inflammation. Their role as mediators of inflammation may have significant implications for a range of lung diseases in which inflammation is a central element of pathogenesis. Chronic obstructive pulmonary disease (COPD), a highly prevalent and morbid condition predominantly affecting cigarette smokers, is a prime example of a respiratory illness with an inflammatory component. Understandably, sphingolipids have received growing attention for their increasingly demonstrated role in the pathophysiology of COPD. The present review aims to be among the first to focus exclusively on the connection between sphingolipids and lung inflammation in COPD, providing the reader with a clinically oriented synopsis of this intriguing association. Sphingolipids have been hypothesised to play a role in the pathogenesis of COPD. Progress in the understanding of sphingolipid pathobiology in COPD has identified putative therapeutic targets. http://bit.ly/2KVwbj4
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影响因子：
4.6
作者：
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通讯作者：
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发表时间：
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DOI：
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2014-03-01
影响因子：
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