Regular patterns for proteome-wide distribution of protein abundance across species.
Regular patterns for proteome-wide distribution of protein abundance across species.
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跨物种蛋白质丰度的蛋白质组范围分布的规律模式
DOI：
10.1371/journal.pone.0032423
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发表时间：
2012
期刊：
影响因子：
3.7
通讯作者：
He F
中科院分区：
文献类型：
--
作者：
Zhong F;Yang D;Hao Y;Lin C;Jiang Y;Ying W;Wu S;Zhu Y;Liu S;Yang P;Qian X;He F
生物实体的蛋白质组，包括细胞、组织、器官和生物体，由不同丰度的蛋白质组成。确定蛋白质组中不同蛋白质丰度的原理对于理解生物实体的构建块具有根本意义。在这里，我们报告了蛋白质丰度在人类、小鼠、苍蝇、蠕虫、酵母和细菌等物种的蛋白质组分布中的三种规律：在大多数情况下，蛋白质丰度与蛋白质的起源时间或进化过程中的序列保守性呈正相关;它与蛋白质结构域数目呈负相关，与蛋白质结构域覆盖率呈正相关，在进化过程中，这种相关性变得更强;蛋白质丰度可以根据蛋白质的功能进一步分层，其中作用于物质转化和运输的蛋白质（质量类）比作用于信息调制的蛋白质（信息类）更丰富。因此，蛋白质丰度与蛋白质的进化、结构和功能的固有特征内在相关。
A proteome of the bio-entity, including cell, tissue, organ, and organism, consists of proteins of diverse abundance. The principle that determines the abundance of different proteins in a proteome is of fundamental significance for an understanding of the building blocks of the bio-entity. Here, we report three regular patterns in the proteome-wide distribution of protein abundance across species such as human, mouse, fly, worm, yeast, and bacteria: in most cases, protein abundance is positively correlated with the protein's origination time or sequence conservation during evolution; it is negatively correlated with the protein's domain number and positively correlated with domain coverage in protein structure, and the correlations became stronger during the course of evolution; protein abundance can be further stratified by the function of the protein, whereby proteins that act on material conversion and transportation (mass category) are more abundant than those that act on information modulation (information category). Thus, protein abundance is intrinsically related to the protein's inherent characters of evolution, structure, and function.
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